【摘要】 目的：探讨Luminal A型乳腺癌临床病理学及超声特征与腋窝淋巴结转移的关系。方法：研究对象为2016年1月—2022年10月南京医科大学第一附属医院收治的301例Luminal A型乳腺癌女性患者，其中82例为淋巴结转移组，219例为未转移组。采用单因素及多因素logistic回归分析患者临床病理学资料、肿块及腋窝淋巴结超声图像特征与腋窝淋巴结转移的相关性。结果：单因素分析结果显示，超声图像中肿块大小、形态、边缘及腋窝淋巴结超声图像中短径、长径/短径（L/S<2）、淋巴门结构消失、皮质厚度（>3 mm）、血供类型（非淋巴门型）及血流（丰富）差异有统计学意义，与淋巴结转移具有相关性（P<0.05）；多因素logistic回归分析，超声图像中的肿块大小（OR=1.842,P=0.016）、淋巴结皮质厚度（OR=2.649,P=0.036）、L/S(OR=0.354,P=0.007)及淋巴结血流（OR=2.255,P=0.039）是Luminal A型乳腺癌腋窝淋巴结转移的独立影响因素。结论：Luminal A型乳腺癌患者临床病理学及超声特征可以预测腋窝淋巴结转移，为临床医师针对Luminal A型乳腺癌的治疗提供参考。更多还原

【Abstract】 Objective: To investigate the relationship between clinicopathologic and ultrasonographic features of Luminal A breast cancer and axillary lymph node metastasis. Methods: In this study, a total of 301 female patients with Luminal A breast cancer confirmed by pathology in Nanjing Medical University First Hospital from January 2016 to October 2022 were selected, of whom 82were in the lymph node metastasis group and 219 were in the non-metastasis group. The correlation between clinicopathological and ultrasonographic features of Luminal A breast cancer and axillary lymph node metastasis was determined by univariate and logistic regression analyses. Results: The results of univariate analysis showed statistically significant differences in size, shape, margin of tumor and short diameter, long diameter/short diameter(L/S<2), loss of lymphatic portal structures, cortical thickness(>3 mm),type of blood supply(non-lymphoid portal type) and vascularity of lymph node(abundant) between the two groups, which correlated with lymph node metastasis(P<0.05). Logistic regression analysis showed that size of the tumor(OR=1.842, P=0.016), cortical thickness of lymph node(OR=2.649, P=0.036), L/S(OR=0.354, P=0.007) and vascularity of lymph node(OR=2.255, P=0.039)were independent risk factors for axillary lymph node metastasis in Luminal A breast cancer. Conclusion: Clinicopathological and ultrasonographic features of patients with Luminal A breast cancer can predict axillary lymph node metastasis and provide a reference for clinicians in the treatment of Luminal A breast cancer.更多还原