【摘要】 目的 探究血清脑源性神经营养因子（BDNF）、胰高糖素样肽-1（GLP-1）水平变化对阿尔茨海默病患者认知功能障碍的意义。方法 选取2020年1月至2022年7月山东第一医科大学附属中心医院收治的104例阿尔茨海默病患者作为AD组研究对象，选取同期99名健康志愿者作为对照组，两组均进行血清BDNF及GLP-1检测，同时采用神经心理状态评定量表评估AD组的认知功能，对比其检测、评估结果，采用Spearman分析AD患者MMSE评分与血清BDNF、GLP-1水平的相关性。结果 AD组血清BDNF、GLP-1水平均低于对照组，差异有统计学意义（t=13.702、21.395,P<0.05）；不同认知功能障碍程度患者血清BDNF、GLP-1水平：重度<中度<轻度，差异有统计学意义（F=32.983、13.646,P<0.05）;Spearman法分析结果显示，AD患者血清BDNF、GLP-1水平与MMSE评分呈正相关(r_MMSE评分=0.616、r_MMSE评分=0.742,P<0.05)。结论 阿尔茨海默病患者血清BDNF、GLP-1水平变化可有效反映患者认知功能障碍程度，可协助临床进行AD早期检查。更多还原

【Abstract】 Objective To explore the significance of serum brain-derived neurotrophic factor（BDNF）and glucagon like peptide-1（GLP-1）levels in patients with Alzheimer’s disease of cognitive function.Methods 104 patients with Alzheimer’s disease admitted to the Central Hospital Affiliated to Shandong First Medical University from January 2020 to July 2022 were selected as the research objects in the AD group,and 99 healthy volunteers were selected as the research objects in the control group,the serum BDNF was detected in the two groups,at the same time,the neuropsychological state rating scale was used to evaluate the cognitive function of the AD groups,and the detection,evaluation results and correlation were compared,Spearman was used to analyze the correlation between MMSE score and serum BDNF and GLP-1 levels in AD patients.Results The levels of serum BDNF and GLP-1 in the AD group were lower than those in the control group,the difference was statistically significant（t=13.702,t=21.395,P<0.05）. Serum BDNF and GLP-1 levels in patients with different degrees of cognitive dysfunction were severe <moderate <mild,the difference was statistically significant（t=32.983,t=13.646,P<0.05）. Spearman analysis showed that serum BDNF and GLP-1 levels in AD patients were positively correlated with MMSE score(r_{MMSE score}=0.616,r_{MMSE score}=0.742,P<0.05).Conclusion The changes of serum BDNF and GLP-1 levels in patients with Alzheimer ’ s disease can effectively reflect the degree of cognitive dysfunction in patients,and can assist in the early detection of AD in clinic.更多还原