【摘要】 目的 探讨广西地区高尿酸血症在2型糖尿病患者中的流行状况及相关因素，以便针对性干预。方法 回顾性选取2018年3月-2022年10月玉林市第一人民医院收治的2型糖尿病患者2434例作为研究对象。根据所选患者血尿酸（UA）的水平将其分为高尿酸血症组（血UA>420μmol/L）和对照组（血UA≤420μmol/L）。比较两组一般资料及各项指标，并采用多因素Logistic回归分析法分析导致2型糖尿病患者发生高尿酸血症的危险因素。结果 在2434例2型糖尿病患者中，发生高尿酸血症的患者有474例，无高尿酸血症的患者有1960例，其高尿酸血症的发生率为19.47%。经单因素分析可知，高尿酸血症组男性多于女性，高尿酸血症组舒张压、收缩压、BMI、头围、颈围、腰围、臀围、内脏脂肪、皮下脂肪、胰岛素抵抗指数、糖化血红蛋白、Cr、TG、LDL，晨尿白蛋白/肌酐比值均高于对照组，HDL低于对照组，差异有统计学意义（P<0.05）；经多因素Logistic回归分析可知，男性、臀围、肌酐、TG是导致2型糖尿病患者发生高尿酸血症的独立危险因素，HDL为保护性因素，差异有统计学意义（OR>1,P<0.05）。结论 2型糖尿病患者高尿酸血症的发生率较高，导致其发生高尿酸血症的危险因素包括男性、臀围、肌酐、甘油三酯等,而女性及HDL为发生高尿酸血症的保护性因素。临床上应对存在上述危险因素的2型糖尿病患者予以针对性的防治措施，以降低其高尿酸血症的发生风险。更多还原

【Abstract】 Objective To investigate the prevalence and related factors of hyperuricemia in patients with type 2 diabetes mellitus in Guangxi, so as to provide targeted intervention.Methods A total of 2434 patients with trype 2 diabetes mellitus admitted to the First People’s Hospital of Yulin from March 2018 to October 2022 were retrospectively selected as the study subjects. According to the level of serum uric acid(UA), the selected patients were divided into hyperuricemia group(serum UA>420 μmol/L) and control group(serum UA≤420 μmol/L). The general data and indexes of the two groups were compared, and the risk factors of hyperuricemia in type 2 diabetes mellitus patients were analyzed by multivariate Logistic regression analysis.Results Among the 2434 patients with trype 2 diabetes mellitus, 474 patients had hyperuricemia and 1960 patients had no hyperuricemia.The incidence of hyperuricemia was 19.47%. Univariate analysis showed that there were more males than females in the hyperuricemia group, the diastolic blood pressure, systolic blood pressure, BMI, head circumference, neck circumference, waist circumference, hip circumference, visceral fat,subcutaneous fat, insulin resistance index, glycosylated hemoglobin, Cr, TG, LDL, morning urine albumin/creatinine ratio in the hyperuricemia group were higher than those in the control group, and HDL was lower than that in the control group. The difference was statistically significant( P<0.05).Multivariate Logistic regression analysis showed that male, hip circumference, creatinine and TG were independent risk factors for hyperuricemia in trype 2 diabetes mellitus patients, and HDL was a protective factor, the difference was statistically significant( OR >1, P <0.05).Conclusion The incidence of hyperuricemia in patients with trype 2 diabetes mellitus is high. The risk factors for hyperuricemia include male, hip circumference,creatinine, triglyceride, etc., while female and HDL are protective factors for hyperuricemia. Targeted prevention and treatment measures should be taken for trype 2 diabetes mellitus patients with the above risk factors to reduce the risk of hyperuricemia.更多还原