【摘要】 目的 利用SEER数据库总结原发腮腺淋巴瘤相关的人口学特征、临床特点及预后相关因子。方法 本研究纳入1987-2016年美国SEER数据库登记的原发腮腺B细胞非霍奇金淋巴瘤（NHL）病例。采用倾向评分匹配降低基线水平的混杂因子；K-M曲线进行单因素生存分析；Cox回归模型进行多因素分析；竞争风险回归模型进行原发腮腺淋巴瘤相关的生存分析。结果 共纳入1443例原发腮腺B细胞NHL，经2∶1倾向评分匹配后1170例患者纳入下一步分析，且多因素Cox回归分析显示，年龄与组织学类型是独立的OS预测因素。原发腮腺惰性B细胞NHL中<50、50～59、60～69、70～79及≥80年龄段患者的中位OS分别为275、241、216、121及51个月（P<0.05），组织学类型为MZL、FL及CLL/SLL患者的OS分别为195、180及78个月（P<0.05），且1年及5年生存率分别为97.32%及85.02%。原发腮腺侵袭性B细胞NHL中<50、50～59、60～69、70～79及≥80年龄段患者的中位OS分别为121、203、185、74及12.5个月（P<0.05），且1年及5年生存率分别为84.92%及62.81%。共有546例死亡病例，最常见的死亡原因为NHL，其次为心脏病。竞争风险回归分析表明，年龄、组织学类型、Ann Arbor分期、诊断时间影响原发腮腺惰性B细胞NHL特异性死亡；年龄影响原发腮腺侵袭性B细胞NHL特异性死亡。结论 原发腮腺B细胞淋巴瘤主要的组织学亚型是MZL，组织学亚型和年龄与原发腮腺B细胞NHL预后密切相关。更多还原

【Abstract】 Objective To summarize the demographic characteristics, clinical characteristics and prognostic factors of primary parotid lymphoma by SEER database.Methods Primary parotid B-cell non-Hodgkin’s lymphoma(NHL) cases registered in the US SEER database from 1987 to 2016were included. Propensity score matching was used to reduce the confounding factors at the baseline level. K-M curve was used for single factor survival analysis. Cox regression model was used for multivariate analysis. The survival analysis of primary parotid lymphoma was performed by competitive risk regression model.Results A total of 1443 patients with primary parotid B-cell NHL were included, and 1170 patients were included in the next analysis after 2 ∶1 propensity score matching. Multivariate Cox regression analysis showed that age and histological type were independent predictors of OS. The median OS of patients aged <50,50-59,60-69,70-79 and ≥80 years in primary parotid indolent B-cell NHL was275,241,216,121 and 51 months, respectively(P<0.05); the OS of patients with histological types of MZL, FL and CLL/SLL was 195,180 and 78months, respectively(P<0.05); and the 1-year and 5-year survival rates were 97.32% and 85.02%, respectively. The median OS of patients with age<50,50-59,60-69,70-79, and ≥80 years in primary parotid aggressive B-cell NHL was 121,203,185,74, and 12.5 months, respectively(P <0.05), and the 1-year and 5-year survival rates were 84.92% and 62.81%, respectively. There were 546 death cases, the most common cause of death was NHL, followed by heart disease. Competitive risk regression analysis showed that age, histological type, Ann Arbor stage and diagnosis time affected the specific death of primary indolent B-cell NHL in parotid gland. Age affects the specific death of primary parotid aggressive B-cell NHL.Conclusion The main histological subtype of primary parotid B-cell lymphoma is MZL. The histological subtype and age are closely related to the prognosis of primary parotid B-cell NHL.更多还原