【摘要】 肌少症是老年慢性心力衰竭(简称心衰)患者常见的并发症,且显著影响老年慢性心衰患者的预后。老年慢性心衰合并肌少症发展机制涉及多种因素,包括蛋白合成和分解代谢失衡、炎症与氧化应激、肌肉失用、营养不良等,目前干预方案尚缺乏统一标准,本文从近年来有关慢性心衰合并肌少症的病因及发展机制,以及运动干预、营养支持、药物治疗、体外反搏等干预研究进展进行综述。更多还原

【Abstract】 Sarcopenia has been found to be frequently associated with co-morbidity among patients with chronic heart failure(CHF)and significantly affects the prognosis of the elderly with heart failure.Research studies in recent years indicate that protein synthesis and catabolic imbalance,inflammation,oxidative stress,muscle apraxia,and malnutrition play roles in the pathogenesis of sarcopenia induced by chronic heart failure in the elderly.There are few confirmed effective interventions for sarcopenia with CHF.This article reviews the recent advances in pathogenesis and interventions,including exercise intervention,nutritional support,drug therapy and ecp external counterpulsation,of chronic heart failure in the elderly complicated with sarcopenia.更多还原