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1例多因素所致药物性肝损伤病例的病因论证与药学监护

Etiology demonstration and pharmaceutical care of a case of multi-factor drug-induced liver injury

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【作者】 徐媛方忠宏冉姗

【Author】 Yuan XU;Zhong-Hong FANG;Shan RAN;Department of Pharmacy,Jinshan Dental Disease Center;Department of Pharmacy, Jinshan Hospital of Fudan University;

【通讯作者】 冉姗;

【机构】 上海市金山区牙病防治所药剂科复旦大学附属金山医院药剂科

【摘要】 临床药师参与1例多因素导致的药物性肝损伤(DILI)病例的病情与病因调查、论证、总结病因药物与治疗过程,为患者提供药学监护,并提出用药建议。临床药师建议停用有关药物,并进行用药教育与警示,治疗10 d后患者病情与肝生化指标明显好转、出院。2个月后随访患者肝功能各项指标均恢复正常。通过对该病例的报道说明DILI的病因药物鉴别明确至关重要,与最终医疗质量与生命安全相关联。报告DILI,尤其是中药相关DILI,更要做到报告规范、合理。

【Abstract】 Clinical pharmacists participated in the disease and etiology investigation,demonstration, summary of etiological drugs and treatment process of a case of multifactorial drug-induced liver injury(DILI), provided pharmaceutical care for the patient, and put forward medication recommendations. The relevant drugs were stopped, and medication education and warnings were given. A?ter 10 days of treatment, the patient’s condition and liver biochemical indicators improved significantly and discharged from the hospital. A?ter 2 months of follow-up,the liver function indexes of the patients returned to normal. The report of this case indicated that the clear identification of the etiology and drugs of DILI was very important, which was related to the ultimate medical quality and life safety. Reporting DILI, especially DILI related to traditional Chinese medicine, should be standardized and reasonable.

【基金】 2019年上海市临床药学重点专科建设项目(1229)
  • 【文献出处】 药物流行病学杂志 ,Chinese Journal of Pharmacoepidemiology , 编辑部邮箱 ,2023年03期
  • 【分类号】R575
  • 【下载频次】14
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