【摘要】 目的 通过分析医疗用毒性药品（简称“毒性药品”）A型肉毒毒素在医疗机构中的使用情况，探讨和促进毒性药品安全管理。方法 查阅国家发布的毒性药品管理文件，检索国内外相关指南、文献资料，结合实际工作情况，对毒性药品安全管理进行探讨。结果 国家相关部门发布的毒性药品相关法律法规待完善，国外相关指南对该类药品接收、储存、准备、运输、管理或处置等环节提供了相关意见、文献综述和病例报告。本院结合相关法律法规、国内外指南、文献资料和实际工作中出现的问题，对毒性药品在医院中流通的各环节进行管理制度上的严格修订。毒性药品使用存在临床医护人员重视程度不够，药品实际使用量与处方标注用量不符，药物利用指数偏低等情况。结论 国家相关部门应加快毒性药品各项法律法规的更新修订；医疗机构应提高对毒性药品重视程度，持续监督及管理，并结合实际工作情况制定相关制度，共同促进毒性药品安全管理。更多还原

【Abstract】 Objective To explore and promote the safe management of toxic drugs, the usage of type A botulinum toxin in medical institutions will be analyzed. Methods The national documents on toxic drug management were consulted. The relevant guidelines and literature were searched. At last, The usage of medical toxic drugs based on the actual working conditions were analyzed. Results The toxic drug-related laws and regulations released by relevant national departments were mostly outdated. Related guidelines from foreign countries provided opinions, literature reviews and case reports on the reception, storage, preparation, transportation, management or disposal of these drugs. Our hospital revised the management system for the circulation of toxic drugs in various links referring to the relevant laws and regulations,domestic and foreign guidelines, literature, and considering about the problems encountered in actual work. However, in our hospital the clinical medical staff did not give enough emphasis on the use of toxic drugs. Actual drug usage did not match the prescribed dosage and the drug utilization index was low. Conclusion We call on updating and revising the laws and regulations related to toxic drugs to the relevant national departments. Medical institutions should increase their attention to toxic drugs and give the supervision continuously, and develop relevant systems in conjunction with actual work situations to promote the safe management of toxic drugs collectively.更多还原