【摘要】 治疗依从性差是糖尿病患者胰岛素起始治疗后血糖控制不佳的重要原因之一，减少注射次数有助于提高依从性。对于已使用胰岛素治疗的糖尿病患者，以依柯胰岛素（insulin icodec）为代表的胰岛素周制剂提供了注射次数更少的治疗方案。现介绍依柯胰岛素的分子结构和作用机制，并基于依柯胰岛素的两项Ⅲa期临床研究（ONWARDS 2和4）的结果，探讨在已使用胰岛素治疗的2型糖尿病患者中转换为依柯胰岛素治疗的有效性和安全性。更多还原

【Abstract】 Poor adherence after insulin initiation contributes to inadequate glycemic control in patients with diabetes, and reducing the frequency of injections can help improve treatment adherence. Once-weekly insulin such as insulin icodec, provides an optional treatment with fewer injections for patients with diabetes requiring insulin therapy. This article describes the molecular structure and mechanism of action of insulin icodec, and discusses the efficacy and safety of insulin icodec in insulintreated type 2 diabetes based on the results of two phase Ⅲa clinical studies, ONWARDS 2 and 4.更多还原