【摘要】 目的 探究丹参注射液联合美沙拉嗪在溃疡性结肠炎患者中的治疗效果及对炎症因子水平的影响。方法 选取2020年12月至2022年11月江西省樟树市人民医院收治的68例溃疡性结肠炎患者按随机数字表法分为两组，各34例。对照组口服美沙拉嗪肠溶片，观察组在对照组基础上联合丹参注射液治疗，两组均治疗4周。对比两组临床疗效，炎症因子[超敏C反应蛋白（hs-CRP）、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]水平，凝血指标[凝血酶原时间（PT）、凝血酶时间（TT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）]水平及不良反应。结果 观察组治疗总有效率为97.06%(33/34)，高于对照组的73.53%(25/34)，差异有统计学意义（P<0.05）。观察组治疗后hs-CRP、IL-8、TNF-α水平低于对照组，差异有统计学意义（P<0.05）。观察组治疗后PT、FIB、APTT、TT均低于对照组，差异有统计学意义（P<0.05）。两组不良反应率相比，差异无统计学意义（P>0.05）。结论 在溃疡性结肠炎患者治疗中，丹参注射液与美沙拉嗪联合使用，可有效遏制炎症反应，改善凝血功能，且无明显不良反应，安全可靠，值得临床推广。更多还原

【Abstract】 Objective To explore the therapeutic effect of danshen injection combined with mesalazine in patients with ulcerative colitis and its influence on inflammatory factors. Methods 68 patients with ulcerative colitis treated in Zhangshu City People’s Hospital from December 2020 to November 2022 were selected and divided into two groups according to random number table method, with 34 cases in each group. The control group was treated with mesalazine enteric-coated tablets, and the observation group was treated with danshen injection on the basis of the control group. Both groups were treated for 4weeks. The clinical efficacy, levels of inflammatory factors [hypersensitive C-reactive protein(hs-CRP), interleukin-8(IL-8), tumor necrosis factor-α(TNF-α)], and coagulation indexes [prothrombin time(PT), thrombin time(TT), activated partial thromboplastin time(APTT), fibrinogen(FIB)] and adverse reaction were compared between the two groups. Results The total effective rate of the observation group was 97.06%(33/34), which was higher than that of the control group 73.53%(25/34),the difference was statistically significant(P<0.05). After treatment, the levels of hs-CRP, IL-8 and TNF-α in observation group were lower than those in control group; PT, FIB, APTT and TT in observation group were lower than those in control group, the difference were statistically significant(P<0.05). There was no significant difference in the rate of adverse reactions between the two groups(P>0.05). Conclusion In the treatment of ulcerative colitis patients, the combined use of danshen injection and mesalazine has a good effect, which can effectively curb inflammation and improve coagulation function without obvious adverse reactions, and is safe and reliable, worthy of clinical promotion.更多还原