【摘要】 目的 对比分析单纯甲状腺癌、甲状腺癌合并桥本氏甲状腺炎（HT）的患者的临床病理特点。方法 回顾性选取安阳市肿瘤医院甲状腺头颈外科2017年1月至2022年1月收治的甲状腺癌患者237例，根据是否合并HT分为合并组及未合并组。合并组为甲状腺癌合并HT，未合并组为未合并HT的单纯甲状腺癌。比较两组患者的一般资料、病理类型、临床分期、超声表现、甲状腺功能、术后病理特点及预后情况。结果 与未合并组比较，合并组女性比例高，发病年龄较小（P<0.05）；超声检查结果显示，合并组粗大钙化检出占比、丰富血流信号检出率高于未合并组（P<0.05）；合并组促甲状腺激素（TSH）、甲状腺球蛋白抗体（Tg-Ab）、甲状腺过氧化物酶抗体（TPO-Ab）水平高于未合并组（P<0.05）。术后病理结果显示，合并组中颈部淋巴结转移发生率、包膜外侵犯发生率均低于未合并组（P<0.05）。结论 HT与甲状腺癌之间具有一定的相互关联。甲状腺癌合并HT患者女性居多且年龄偏小，病灶相对较小，而周围侵犯、淋巴结转移以及远处转移者少见，其预后可能相对良好，对其内在机制的深入研究可能会为甲状腺癌患者的诊治带来更为精确的方案。更多还原

【Abstract】 【Objective】 To compare and analyze the clinicopathological characteristics of patients with simple thyroid cancer,thyroid cancer with Hashimoto’s thyroiditis. 【Methods】 Totally 237 patients with thyroid cancer admitted to our department of thyroid head and neck surgery from January 2017 to January 2022 were retrospectively selected, and were divided into the merged group and the unmerged group according to whether Hashimoto’s thyroiditis was combined. The merged group was thyroid cancer combined with Hashimoto’s thyroiditis, and the unmerged group was simple thyroid cancer without Hashimoto’s thyroiditis. The general data, pathological types, clinical stages, ultrasonic manifestations, thyroid function, postoperative pathological characteristics and prognosis were compared between the two groups. 【Results】 The proportion of female in the merged group was higher, and the age of onset was younger compared with unmerged group(P<0.05). The ultrasonic examination results showed the proportion of gross calcification and rich blood flow signals in the merged group were higher than those in the unmerged group(P<0.05). The levels of TSH, Tg-Ab and TPo-Ab in the merged group were higher than those in the unmerged group(P<0.05).Postoperative pathological results showed the incidence of cervical lymph node metastasis and extracapsular invasion in the merged group were lower than those in the unmerged group(P<0.05). 【Conclusion】 Hashimoto’s thyroiditis is correlated with thyroid cancer. The majority of patients with thyroid cancer combined with Hashimoto’s thyroiditis are women and young. The focus is relatively small, while peripheral invasion, lymph node metastasis and distant metastasis are rare. The prognosis may be relatively good. The in-depth study of its internal mechanism may bring more accurate solutions for the diagnosis and treatment of thyroid cancer patients.更多还原