【摘要】 目的 探讨MRI在三维适形¹²⁵I近距离放射治疗对于非转移性去势抵抗性前列腺癌（nonmetastatic castration-resistant prostate cancer, nCRPC）治疗前的应用价值。方法 选取13例接受¹²⁵I放射性粒子永久性近距离挽救性放疗的nCRPC患者，治疗前行MRI检查，分析MRI影像特征。结果 前列腺癌Gleason评分（7.08±0.95）分，术前PSA平均（6.27±4.37） ng/ml。PSA升至术前水平时间（11.1±3.9）个月；PSA上升至术前水平的时间与术前PSA呈负的直线相关关系。所有患者无尿潴留、放射性膀胱炎、放射性直肠炎、尿道狭窄等并发症；患者住院时间平均为（5.6±1.5）天，术后住院（1.8±0.8）天。结论 MRI检查在三维适形¹²⁵I近距离放射治疗对于非转移去势抵抗性前列腺癌治疗前的效果良好，PSA上升至术前水平的时间与术前PSA呈负的直线相关关系。更多还原

【Abstract】 Objective To investigate the efficacy of three-dimensional conformal ¹²⁵I brachytherapy in the treatment of non metastatic castration resistant prostate cancer（ncrpc）. Methods 13 patients with ncrpc received ¹²⁵I radioactive particle permanent brachytherapy. Results The gleason score of prostate cancer was（7.08±0.95）, and the average preoperative PSA was（6.27±4.37） ng/ml. The time of PSA rising to preoperative level was（11.1±3.9） months; There was a negative linear correlation between the time of PSA rising to preoperative level and preoperative PSA(r²=. All patients had no complications such as urinary retention, radioactive cystitis, radioactive proctitis, urethral stricture, etc.; the average length of hospital stay was（5.6±1.5） days, and the postoperative hospital stay was（1.8±0.8） days. Conclusion For non metastatic hormone resistant prostate cancer, the effect of three-dimensional conformal ¹²⁵I brachytherapy is positive. For patients, the trauma is small and the recovery is fast. The time when PSA rises to the preoperative level has a negative linear correlation with preoperative PSA.更多还原