【摘要】 IL-17作为一种重要的炎症细胞因子，在抗感染及自身免疫疾病中发挥重要作用，其已被证实在多种恶性肿瘤的发生及发展过程中也发挥重要作用。近年来，卵巢癌的全球病死率虽有所下降，但有年轻化趋势。IL-17与卵巢癌的相关研究显示，IL-17可作为卵巢癌检测、治疗及随访过程中重要的生物学标志物，但仍缺乏大样本量的系统性研究。目前针对IL-17的肿瘤免疫治疗正在进行临床研究。该文总结近年IL-17在卵巢癌中的研究进展，为卵巢癌的早期发现、治疗及术后随访提供新的思路。更多还原

【Abstract】 As an important inflammatory cytokine, interleukin-17(IL-17) plays a critical immune role in anti-infection and autoimmune diseases. Besides, IL-17 has been confirmed to play a pivotal role in the occurrence and progression of multiple malignant tumors. In recent years, the global mortality rate of ovarian cancer has been decreased, but there is a trend of younger women being diagnosed. According to the correlation studies between IL-17 and ovarian cancer, it can be predicted that IL-17 can serve as a critical biomarker in the detection, treatment and follow-up of ovarian cancer. Nevertheless, large sample size studies are urgently required. Currently, clinical trials related to the role of IL-17 in the immune therapy for multiple tumors are being undertaken. In this article, recent studies related to the role of IL-17 in ovarian cancer were reviewed, which might provide novel ideas for early detection, treatment and postoperative follow-up of ovarian cancer.更多还原