【摘要】 金属蛋白酶-7(MMP-7)是锌依赖性内肽酶家族中的重要成员，其参与细胞外基质中各种蛋白质的降解，且在白细胞浸润和组织炎症中也发挥重要作用。MMP-7在正常肝脏中不表达或很少表达，而在胆道闭锁中表达增强。研究发现MMP-7能够有效地鉴别胆道闭锁与其他胆汁淤积性疾病，对胆道闭锁的诊断有很高的敏感性和特异性，对胆道闭锁的肝衰竭和肝移植有一定的预测作用。因此，提高对MMP-7的认识，早期诊断胆道闭锁是当今研究的热点。现对MMP-7在胆道闭锁的研究进行综述，以期为胆道闭锁的临床诊断、预后评估和治疗胆道闭锁提供参考。更多还原

【Abstract】 Metalloproteinase-7(MMP-7) is an important member of the zinc-dependent endopeptidase family. It participates in the degradation of various proteins in the extracellular matrix, and also plays an important role in leukocyte infiltration and tissue inflammation.MMP-7 was not expressed or rarely expressed in normal liver, but increased in biliary atresia. The study found that MMP-7 can effectively differentiate biliary atresia from other cholestasis diseases, has high sensitivity and specificity in the diagnosis of biliary atresia, and has a certain predictive role in liver failure and liver transplantation of biliary atresia. Therefore, improving the understanding of MMP-7 and early diagnosis of biliary atresia are the focus of current research. This article reviews the research of MMP-7 in biliary atresia in order to provide reference value for the clinical diagnosis, prognosis evaluation and treatment of biliary atresia.更多还原