【摘要】 目的 探讨给药频次对早产新生儿万古霉素谷浓度(C0)的影响。方法 选取2017年9月至2021年5月该院新生儿重症监护室中使用万古霉素的早产新生儿189例，根据相关指南中万古霉素C0推荐剂量将早产新生儿分为M组(102例，5～15 mg/mL)、L组(28例，<5 mg/mL)、H组(59例，>15 mg/mL)。同时根据给药频次将早产新生儿分为每天1次(qd)组(23例)、每12小时1次(q12)组(90例)、每8小时1次(q8)组(76例)。比较各组间万古霉素C0变化情况，分析给药频次对早产新生儿万古霉素C0的影响。结果 189例早产新生儿中，采用指南推荐剂量(5～15 mg/mL)的仅占53.96%。不同C0组胎龄、体重、药物剂量及肾功能相关指标比较，差异无统计学意义(P>0.05)。不同给药频次组早产新生儿分布情况比较，差异有统计学意义(P=0.024)。q8组、q12组万古霉素C0均值分别与qd组比较，差异有统计学意义(P<0.05),而q8组与q12组比较，差异无统计学意义(P>0.05)。结论 在早产新生儿中按qd频次给药能更好地提高万古霉素C0达标率，同时可避免血药浓度过高造成的不良反应。更多还原

【Abstract】 Objective To investigate the effect of administration frequency on vancomycin valley concentration(C0) in premature neonates.Methods 189 premature neonates receiving vancomycin in the neonatal intensive care unit of this hospital from September 2017 to May 2021 were selected.According to the recommended dose of vancomycin C0 in the relevant guidelines, the premature neonates were divided into the M group(102 cases, 5-15 mg/mL),the L group(28 cases, <5 mg/mL),and the H group(59 cases, >15 mg/mL).At the same time, according to the frequency of administration, the premature neonates were divided into three groups: the once a day(qd) group(23 cases),the once every 12 hours(q12) group(90 cases),and the once every 8 hours(q8) group(76 cases).The changes of vancomycin C0 in each group were compared, and the effects of administration frequency on vancomycin C0 in the premature neonates were analyzed.Results Among the 189 premature neonates, only 53.96% received the dosage recommended by the guidelines(5-15 mg/mL).There were no statistically significant differences in gestational age, body weight, drug dose and related indexes of renal function among different C0 groups(P>0.05).There was statistically significant difference in the distribution of premature neonates among the different administration frequency groups(P=0.024).The mean value of vancomycin C0 in the q8 group and the q12 group was significantly different from that in the qd group(P<0.05),but there was no significant difference between the q8 group and the q12 group(P>0.05).Conclusion The administration of vancomycin C0 at the frequency of qd in premature neonates can better improve the rate of reaching the standard and avoid adverse reactions caused by high blood drug concentration.更多还原