【摘要】 子宫内膜周期性改变过程中的失调均可导致子宫内膜相关疾病的发生、发展，从而影响妇女健康。目前，由于缺乏表征子宫内膜发生、发展特性的研究模型，子宫内膜疾病发病机制研究和治疗药物开发受到一定限制。类器官是一种干细胞来源或原始组织来源的三维培养细胞群，由于其遗传特征、组织学特征、生物学特征与原始组织、器官的一致性，可代表来源器官或组织的功能。可传代扩增的子宫内膜类器官研究模型能保持基因组稳定性，弥补了传统细胞与动物模型的不足。该文综述了子宫内膜类器官模型的优势及其组织学特征、遗传学特征、生物学特征及其相关应用。更多还原

【Abstract】 Dysregulation of endometrial cyclic changes can lead to the development and progression of endometrium-related diseases, which can affect women′s health.Currently, research on the pathogenesis of endometrial diseases and the development of therapeutic drugs are limited by the lack of research models characterizing the onset and development of endometrium.Organoid is a three-dimensional cultured cell population of stem cell origin or primary tissue origin that can represent the function of the source organ or tissue due to the consistency of its genetic, histological, and biological characteristics with those of the primary tissue or organ.The passage-expandable endometrial organoid research model can maintain genomic stability and compensate for the shortcomings of traditional cell and animal models.This article reviewed the advantages of endometrioid organ models and their histological features, genetic features, biological features, and their related applications.更多还原