【摘要】 糖尿病肾病(diabetic nephropathy, DN)是糖尿病发展过程中的肾脏微血管病变，是导致终末期肾病的最常见原因。DN的发病机制尚未阐明，目前认为氧化应激和炎症反应在发病过程中起重要作用。DN迄今尚没有较为有效的干预手段。目前的大量研究证明，核因子E2相关因子2(Nrf2)/血红素加氧酶1(HO-1)通路是与DN的发生发展关系密切的重要信号通路，参与机体的抗氧化应激、抗炎反应。研究发现，某些中药活性物质和中药复方可通过调控Nrf2/HO-1信号通路来抗氧化应激、抗炎，从而改善患者的肾功能及延缓肾纤维化。本文阐述了Nrf2/HO-1信号通路的概述及其与DN的关系，并对近年来基于该通路干预DN的中药的研究进展进行了综述。更多还原

【Abstract】 Diabetic nephropathy is a microvascular lesion of the kidney in the development of diabetes, which is the most common cause of end-stage renal disease. The pathogenesis of diabetic nephropathy has not been elucidated. Oxidative stress and inflammatory response are believed to play important roles in the pathogenesis. At present, diabetic nephropathy has no relatively effective intervention means. A large number of studies now have proved that the nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1) pathway is an important signaling pathway closely related to the occurrence and development of diabetic nephropathy, participating in the body’s antioxidant stress and anti-inflammatory reactions. It has been found that some active substances of traditional Chinese medicine and compound prescription of traditional Chinese medicine can regulate Nrf2/HO-1 signal pathway to resist oxidative stress and inflammation, thereby improving renal function and delaying renal fibrosis in patients. This article describes the Nrf2/HO-1 signaling pathway and its relationship with DN, and reviews the research progress of traditional Chinese medicine for diabetic nephropathy intervention based on this pathway in recent years.更多还原