【摘要】 目的：探讨光活化消毒(PAD)与盐酸米诺环素软膏辅助龈下刮治及根面平整术(SRP)治疗中重度慢性牙周炎的效果。方法：选取2019年1月—2022年1月就诊于昆明市第一人民医院口腔科的中重度牙周炎患者23例作为研究对象，共纳入142颗牙218个位点，其中中度牙周炎169个位点，米诺环素试验组43个，PAD试验组42个，联合试验组41个，对照组43个；重度牙周炎49个位点，米诺环素试验组13个，PAD试验组11个，联合试验组14个，对照组11个。比较四组中、重度牙周炎患者探诊深度(PD)、附着丧失(AT)、探诊出血(BOP)牙周指标。结果：(1)中度牙周炎患者：治疗后6周，PAD试验组和联合试验组PD低于对照组，差异有统计学意义(P<0.05)。治疗后12周，四组PD、AL、BOP均低于治疗前，差异有统计学意义(P<0.05)；联合试验组PD低于对照组，AL低于对照组，差异有统计学意义(P<0.05)。(2)重度牙周炎患者：治疗后6周，米诺环素试验组、PAD试验组、联合试验组PD、AL均低于对照组，差异有统计学意义(P<0.05);PAD试验组BOP低于对照组，差异有统计学意义(P<0.05)。治疗后12周，四组PD、AL、BOP均低于治疗前，差异有统计学意义(P<0.05); PAD试验组和联合试验组PD均低于对照组，差异有统计学意义(P<0.05)。结论：三种辅助治疗中，PAD对牙周指标的改善效果优于米诺环素，可替代米诺环素作为SRP的辅助治疗；联合使用PAD和米诺环素辅助治疗，能持续减小牙周袋深度，控制出血和附着丧失，有更好的抗菌潜能和预后。更多还原

【Abstract】 Objective: To investigate the effect of photo-activated disinfection(PAD) and minocycline hydrochloride ointment assisted scaling and root planing(SRP) in the treatment of moderate-severe chronic periodontitis. Methods: A total of 23 patients with moderate-severe periodontitis who visited the Department of Stomatology, The First People’s Hospital of Kunming from January 2019 to January 2022 were selected as the study subjects. A total of 218 sites in 142 teeth were included, there were 169sites of moderate periodontitis, including 43 sites in minocycline test group, 42 sites in PAD test group, 41 sites in combined test group and 43 sites in control group; There were 49 sites of severe periodontitis, including 13 sites in minocycline test group, 11 sites in PAD test group, 14 sites in combined test group and 11 sites in control group. The periodontal indexes of moderate-severe chronic periodontitis in four groups, such as probing depth(PD), loss of attachment(AT), and bleeding on probing(BOP) were compared. Results:(1) Patients with moderate periodontitis: at 6 weeks after treatment, the PD in the PAD test group and the combined test group was lower than that in the control group, and the difference was statistically significant(P<0.05). At 12 weeks after treatment, the PD, AL and BOP in the four groups were lower than those before treatment, and the differences were statistically significant(P<0.05). The PD in the combined test group was lower than that in the control group and the AL in the combined test group was lower than that in the control group, and the difference was statistically significant(P<0.05).(2) Patients with severe periodontitis: at 6 weeks after treatment, the PD and AL in minocycline test group, PAD test group and combined test group were lower than those in the control group, and the difference was statistically significant(P<0.05); The BOP in the PAD test group was lower than that in the control group, and the difference was statistically significant(P<0.05). At 12 weeks after treatment, the PD,AL and BOP in the four groups were lower than those before treatment, and the differences were statistically significant(P<0.05).The PD in the PAD test group and the combined test group was lower than that in the control group, and the difference was statistically significant(P<0.05). Conclusion: Among the three adjuvant therapies, the improvement effect of PAD on periodontal indexes is better than that of minocycline, and it can replace minocycline as an adjuvant treatment for SRP. The combination of PAD and minocycline adjuvant therapy can continuously reduce periodontal pocket depth, control bleeding and attachment loss,and have better antibacterial potential and prognosis.更多还原