【摘要】 HIV-1 Tat蛋白是HIV-1病毒基因表达的重要调控蛋白,其通过与不同的细胞分子及信号通路相互作用来调控细胞过程。Tat蛋白由感染细胞产生,也可由感染细胞产生后分泌而作用于其他细胞;因此,它既能影响感染细胞,也能影响未感染细胞。Tat蛋白积聚在细胞核中,但根据其表达水平的不同,其可能会定位于核质或核仁,并发挥不同的核效应。该文针对Tat蛋白的结构、核输入机制及细胞核效应的研究进展进行概述。更多还原

【Abstract】 The HIV-1 Tat protein is an important regulator of HIV-1 viral gene expression and regulates cellular processes by interacting with different cellular molecules and signalling pathways. Tat protein is produced by infected cells and can also be secreted by infected cells to act on other cells; Therefore, it can affect both infected and uninfected cells. Tat protein accumulates in the nucleus, but depending on its different expression level, it may be localized in the nucleoplasm or nucleolus and exerts different nuclear effects. This article provides an overview of the structure, nuclear import mechanisms and nuclear effects of Tat proteins.更多还原