【摘要】 水凝胶(hydrogel)是一类极为亲水的高分子材料,可模拟体内神经干细胞所处的细胞外微环境,作为神经干细胞的载体用于干细胞移植疗法。优化水凝胶的理化特性有利于促进移植的神经干细胞的存活、分化和迁移。水凝胶的理化特性包括基质成分、黏弹性、硬度、降解性、导电性以及水凝胶对物理刺激的响应等。该文综述了水凝胶的不同理化特性对神经干细胞命运的影响和水凝胶结合的神经干细胞在中枢神经系统修复中的应用,为通过调节水凝胶理化特性促进中枢神经系统修复提供线索和见解。更多还原

【Abstract】 Hydrogel is one type of highly hydrophilic polymer materials that can simulate the extracellular microenvironment of NSCs(neural stem cells), and it can be used as the carrier of NSCs for cell transplantation therapy. Refining the physicochemical properties of hydrogels can promote survival, differentiation and migration of the transplanted NSCs. The physicochemical properties of hydrogels include matrix composition, viscoelasticity,hardness, degradability, conductivty and the response to physical stimuli. Here this paper reviews the role of hydrogel physicochemical properties in NSC fate regulation and the application of hydrogel-carried NSCs in CNS(central nervous system) repair. This review provides clues and insights to promote CNS repair by modulating hydrogel physicochemical characteristics.更多还原