【摘要】 卡波西肉瘤（KS）又名多发性特发性出血性肉瘤，是一种多中心性血管性肿瘤，发病机制复杂不明，临床上主要分为经典型、地方型、医源型及获得性免疫缺陷综合征相关型四种类型，并在基因组学、转录组学、蛋白质组学以及代谢组学层面均有特征。随着高通量测序等技术的发展，组学研究贡献了大量数据，为卡波西肉瘤的发病机制提供丰富的实验依据。不同类型卡波西肉瘤基因、蛋白表达及代谢特征存在显著不同，卡波西肉瘤相关疱疹病毒（KSHV）也在多种水平存在差异，通过多组学数据的综合分析使各组学互通互联，综合分析结合了不同组织学类型的数据，可提供更深入的疾病信息。本文对近年来各组学技术在卡波西肉瘤中应用进行综述，期望为研究卡波西肉瘤的发生发展机制、治疗及预后提供新的思路，为相关发病机制及诊疗方案奠定理论基础。更多还原

【Abstract】 Kaposi sarcoma(KS), also known as multiple idiopathic hemorrhagic sarcoma, is a multicentric vascular tumor with a complex and unknown pathogenesis. In clinical practice, it is mainly divided into four types, including classical type, endemic type, iatrogenic type, and acquired immunodeficiency syndrome-related type, and has characteristics at the level of genomics, transcriptomics, proteomics, and metabolomics. With the development of technologies such as high-throughput sequencing, omics studies have contributed a wealth of data that provide a rich experimental basis for the pathogenesis of KS. The genetic, protein expression and metabolic characteristics of different types of KS differ significantly, and Kaposi’s sarcoma-associated herpesvirus(KSHV) also varies at multiple levels.Various omics were interconnected through a comprehensive analysis of multi-omics data, which can provide deeper information about the disease. This paper reviews the application of multi-omics techniques in KS in recent years, hopes to provide new ideas on the development, treatment and prognosis of KS, and develops a theoretical foundation for the relevant pathogenesis and diagnosis and treatment plans.更多还原