【摘要】 目的 探究HIV感染者急性期血浆CXCL13水平与病毒载量及CD4细胞数量间的关系，评估其预测疾病进展及ART后免疫重建的能力。方法 选取中国医科大学附属第一医院急性期HIV感染者54例，对标本CXCL13水平、病毒载量和CD4细胞数量进行检测。结果 以set-point高低分组，set-point高组（lgVL≥3.5拷贝/mL）CXCL13水平明显高于set-point低组（lgVL<3.5拷贝/mL,P=0.013 5），以感染一年的CD4细胞数量高低分组，CD4细胞高组（≥500个/μL）CXCL13水平明显低于CD4细胞低组（<500个/μL,P=0.005 7），以ART一年的CD4细胞数量高低分组，CD4细胞高组（≥500个/μL）CXCL13水平明显低于CD4细胞低组（<500个/μL,P=0.025 7）,Kaplan-Meier生存分析显示急性期血浆CXCL13水平高的HIV感染者，其疾病进展更快，ART后免疫恢复更差（P=0.035 1;P=0.000 5）。结论 急性期血浆CXCL13水平可以预测HIV感染的疾病进展及ART后的免疫恢复。更多还原

【Abstract】 Objective To explore the relationship between plasma CXCL13 level during primary infection and HIV viral parameters such as viral loads and CD4~+T cell counts, to evaluate its ability to predict disease progression and immune restoration after antiviral therapy(ART). Methods A total of 54 HIV-infected individuals were selected from The First Affiliated Hospital of China Medical University. The plasma CXCL13 level, the viral loads, and the CD4~+T cell counts were tested. Results Plasma CXCL13 level in the high set-point group(lgVL ≥3.5 copies/mL) was higher than that in the low set-point group(lgVL <3.5 copies/mL, P=0.0135). It was also significantly lower in the high CD4~+T cell group(CD4~+T ≥500 cells/μL within one year after HIV infection) than that in the low CD4~+T cell group(CD4~+T <500cells/μL within one year after HIV infection, P=0.0057). Plasma CXCL13 level was significantly lower in people with CD4~+T ≥500 cells/μL within one year after ART, compared with those with CD4~+T <500 cells/μL within one year after ART(P=0.0257). Kaplan-Meier survival analysis showed that HIV-infected individuals with high CXCL13 levels during primary infection had faster disease progression and poorer immune restoration after ART(P=0.0351; P=0.0005).Conclusions The CXCL13 level during primary infection can predict HIV disease progression and immune restoration after ART.更多还原