【摘要】 目的 了解南京市MSM发生高危行为后暴露后预防（PEP）的使用意愿及影响因素。方法 2022年4月12日至5月18日，通过南京市社会组织进行研究对象招募，收集MSM人口学信息、性行为特征、PEP知识知晓情况及使用意愿等。以PEP使用意愿为因变量，分别进行单因素及多因素Logistics回归分析，探讨使用意愿的影响因素。结果 696名研究对象，236人（33.9%）知晓暴露后预防知识，554人（79.6%）如果发生感染HIV的高危行为愿意采用PEP。多因素Logistic回归结果显示，研究生及以上学历（OR=9.800,95%CI:3.138～30.608），咨询过PEP(OR=50.361,95%CI:18.170～139.582)，知晓PEP知识（OR=15.168,95%CI:5.323～43.219）是PEP使用意愿的促进因素。年龄≥30岁（OR=0.495,95%CI:0.301～0.815）是PEP使用意愿的阻碍因素。结论 南京市MSM PEP使用意愿较高，但知晓率尚待进一步提高，应进一步加强MSM的健康教育，尤其是年龄30岁以上的人群。更多还原

【Abstract】 Objective To understand the willingness to use post-exposure prevention(PEP) and its influencing factors after high-risk behaviors among men who have sex with men(MSM) in Nanjing. Methods From April 12 to May 18, 2022, we recruited research objects through social organizations in Nanjing to collect demographic information, sexual behavior characteristics, awareness of post-exposure prevention knowledge, and the willingness to use post-exposure prevention among MSM. To use PEP as the dependent variable, univariable and multivariable logistic regression analyses were conducted to explore the influencing factors of the intention to PEP. Results Among the 696 subjects, 236(33.9%)knew knowledge of PEP and 554(79.6%) had willing to use PEP if they had HIV-related high-risk behaviors. Multivariate logistic regression showed that PEP promoting factors included having consulted for PEP in the past(OR=50.361, 95%CI:18.170-139.582), having an education level of postgraduate and above(OR=9.800, 95%CI: 3.138-30.608), and having good knowledge of PEP(OR=15.168, 95%CI: 5.323-43.219). Age ≥30(OR=0.495, 95%CI: 0.301-0.815) was a barrier to intention to use PEP. Conclusions MSM in Nanjing have a high willingness to use PEP, but the awareness needs to be further improved. The health education of MSM should be further strengthened, especially for those aged above 30.更多还原