【摘要】 动脉粥样硬化性心脏病目前是HIV/AIDS患者死亡的主要原因之一，也是HIV/AIDS患者慢病管理的重要一环。然而，HIV/AIDS患者动脉粥样硬化性心脏病的发生机制仍不完全清楚。研究表明，慢性持续性炎症是HIV/AIDS患者心血管疾病发生的主要诱因。CX3CL1/CX3CR1是重要的炎症性趋化因子，HIV/AIDS患者中CX3CL1/CX3CR1的表达上调，可通过细胞趋化作用、炎性反应等参与动脉粥样硬化（AS）的形成。因此，了解CX3CL1/CX3CR1在HIV/AIDS患者动脉粥样硬化过程中的作用机制有助于研发新的干预措施，延缓甚至预防HIV/AIDS患者动脉粥样硬化性心脏病的发生发展。本文将从CX3CL1/CX3CR1与动脉粥样硬化的关系，CX3CL1/CX3CR1在HIV/AIDS患者动脉粥样硬化性心脏病中的作用机制等方面进行综述。更多还原

【Abstract】 Atherosclerotic heart disease is currently one of the leading causes of death in people living with HIV(PLWH), and it is also an important part of chronic disease management. However, the pathogenesis of atherosclerotic heart disease in PLWH remains unclear. Persistent inflammation is found to be the main inducer of cardiovascular disease among PLWH. As an important inflammatory chemokine, the up-regulated CX3CL1/CX3CR1 can participate in the formation of atherosclerosis(AS) through cell chemotaxis, inflammatory response. Therefore, it is helpful to understand the role of CX3CL1/CX3CR1 in atherosclerosis among PLWH, and to develop new interventions to delay or even prevent atherosclerotic heart disease. This article reviewed the research progress on the relationship between CX3CL1/CX3CR1and AS, and the role of CX3CL1/CX3CR1 in atherosclerotic heart disease among PLWH.更多还原