【摘要】 目的 了解南京市有艾滋病相关高危行为大学生对使用暴露前预防（PrEP）的意愿，并分析影响PrEP使用意愿的相关因素，为今后在大学生中开展行为干预提供科学依据。方法 采用分层随机整群抽样，于2019年4-6月抽取南京市19所高校在校大学生开展匿名在线调查。调查内容包括，一般人口学特征、艾滋病相关知识知晓情况、艾滋病相关高危行为发生情况和PrEP使用意愿情况等，使用结构方程模型分析大学生PrEP使用意愿的影响因素。结果 共55 974名大学生参与调查，其中2 725名大学生存在艾滋病相关高危行为，19.6%(533/2 725)大学生有PrEP使用意愿。结构方程模型分析结果显示既往患有性病、近一年接受过艾滋病宣传、近一年有HIV检测史、近一年使用过助性剂、男性和近一年有多性伴行为史对高危行为大学生PrEP使用意愿发挥正向作用，路径系数分别为0.18、0.16、0.15、0.09、0.06和0.04;HIV相关知识水平与近一年既往使用过助性剂和既往患有性病发挥负向作用，路径系数分别为-0.25和-0.17。结论 有艾滋病相关高危行为的大学生PrEP使用意愿较低，接受过艾滋病相关知识宣传以及有过HIV检测行为的大学生倾向于使用PrEP，需推动HIV自检试剂进校园，加强学校艾滋病和PrEP相关知识宣传。更多还原

【Abstract】 Objective To understand the willingness to use pre-exposure prophylaxis(PrEP) and influencing factors among college students with AIDS-related high-risk behaviors in Nanjing to provide a scientific basis for behavioral intervention among college students. Methods The students of 19 colleges in Nanjing were sampled using stratified random cluster sampling. Anonymous online questionnaire survey was conducted from April to June 2019. The survey collected demographic characteristics, the awareness of AIDS-related knowledge, the occurrence of high-risk behavior and the willingness to use the PrEP. The structural equation modeling was used to analyze the influencing factors of college students’ intention to use PrEP. Results A total of 55974 college students participated in the survey, among which 2725 had AIDS-related high-risk behaviors. The willingness rate of those students to use PrEP was 19.6%(533/2725). Structural equation modeling analysis showed that the college students having sexually transmitted disease(STD), having received AIDS advocacy, having HIV testing, using drugs abusively, being male, and having multiple sexual partners, in the past year played a positive role in their willingness of using PrEP. The effect coefficients were 0.18, 0.16, 0.15, 0.09, 0.06 and 0.04, respectively. HIV-related knowledge level played a negative role among those students with high-risk behaviors and using drugs or with STDs, and the effect coefficients were 0.25 and 0.17, respectively. Conclusions The willingness to use PrEP among college students with AIDS-related high-risk behavior in Nanjing was low. College students who had received AIDS information and had been tested for HIV were more likely to use Pr EP. Therefore it is necessary to promote HIV self-testing kits and strengthen the awareness of AIDS and Pr EP-related knowledge on campus.更多还原