【摘要】 巨噬细胞作为先天免疫系统的重要组成部分，在炎症和感染免疫过程中发挥不可或缺的作用。Notch信号通路是一种保守的信号通路，调控细胞命运并参与许多疾病进程。在炎症和感染过程中Notch信号参与调控巨噬细胞的分化、活化和代谢。我们总结了Notch配受体在不同的炎症和感染性疾病中对巨噬细胞促炎和抗感染免疫功能具有促进作用，在该调节过程中Notch信号与巨噬细胞中的Toll样受体(TLR)信号或包括白细胞介素6(IL-6)、IL-12、肿瘤坏死因子α(TNF-α)等促炎相关细胞因子之间存在相互作用。在感染及炎症疾病中以Notch信号为靶点进行治疗具有一定潜力，同时也存在挑战。更多还原

【Abstract】 Macrophage as a crucial component of innate immunity, plays an important role in inflammation and infection immunity. Notch signal pathway is a highly conserved pathway, which regulates cellular fate and participates in numerous pathological processes. At present, a lot of literature has confirmed the role of Notch signaling in regulating the differentiation, activation and metabolism of macrophage during inflammation and infection. This review focuses on how Notch signaling promotes macrophage pro-inflammatory and anti-infective immune function in different inflammatory and infectious diseases. In this regulation, Notch signaling interact with TLR signaling in macrophages or inflammatory-related cytokines including IL-6, IL-12, and TNF-α. Additionally, the potential application and challenges of Notch signaling as a therapeutic target against inflammation and infectious diseases are also discussed.更多还原