【摘要】 合成了3个有机锡9-芴酮-4-甲酸酯:三苯基锡9-芴酮-4-甲酸酯[（C₆H₅）₃Sn(C₁₄H₇O₃)]（1）、三环己基锡9-芴酮-4-甲酸酯[(C₆H₁₁)₃Sn(C₁₄H₇O₃)]（2）和三（2-甲基-2-苯基丙基）锡9-芴酮-4-甲酸酯[（C₆H₅C（CH₃）₂CH₂）₃Sn(C₁₄H₇O₃)]（3）。通过元素分析、红外光谱、核磁共振谱(¹H、¹³C和¹¹⁹Sn)、热重分析进行了表征;用单晶X射线衍射方法测定了化合物的晶体结构,并对其进行了量子化学计算和体外抗癌活性研究。结果显示:化合物1为一维链状结构,中心锡原子为五配位的畸变三角双锥构型;化合物2和3均为单核分子,锡原子均为四配位的畸变四面体构型。化合物对人宫颈癌细（HeLa）、人肝癌细胞（HUH-7）、人非小细胞肺癌细胞（A549）、人肺腺癌细胞（H1975）和人乳腺癌细胞（MCF-7）都有较好的抑制活性。更多还原

【Abstract】 Three organotin 9-fluorenone-4-carboxylate compounds,triphenyltin 9-fluorenone-4-carboxylate[（C₆H₅）₃Sn(C₁₄H₇O₃)]（1）,tricyclohexyltin 9-fluorenone-4-carboxylate [(C₆H₁₁)₃Sn(C₁₄H₇O₃)]（2）,and tri（2-methyl-2-phenylpropyl） tin 9-fluorenone-4-carboxylate [（C₆H₅C（CH₃）₂CH₂）₃Sn(C₁₄H₇O₃)]（3）,were synthesized by the solvothermal method using methanol as a solvent.The compounds were characterized by elemental analysis,IR spectroscopy,NMR(¹H,¹³C,and ¹¹⁹Sn),and thermogravimetric analysis.The crystal structures of the compounds were determined by single-crystal X-ray diffraction.The compounds were studied by quantum chemical calculation and in vitro anticancer activity.The results show that compound 1 has a 1D chain structure and the central tin atom is a five-coordinated distorted trigonal bipyramid configuration;compounds 2 and 3 are single tin nuclear molecules and the tin atoms are four-coordinated distorted tetrahedron configurations.The compounds have good inhibitory activity on the human cervical carcinoma cell line（HeLa）,human liver cancer cell line（HUH-7）,human non-small cell lung cancer cell line（A549）,human lung adenocarcinoma cell line（H1975） and breast cancer cell line（MCF-7）.CCDC:2212929,1;2215292,2;2212930,3.更多还原