【摘要】 各种原因所致的慢性肝病在进展过程中往往伴随不同程度或不同类型的睡眠障碍，如：入睡困难、早醒、多梦、日间嗜睡、昼夜颠倒等。慢性肝病患者出现睡眠障碍的主要机制包括昼夜节律紊乱、肝性脑病、肠道菌群失调等，同时越来越多的证据表明，睡眠障碍会严重影响肝病患者的日常生活质量及疾病预后。本文就近年来关于睡眠障碍与慢性肝病之间相互作用的研究作一综述，以期提高临床医师对于肝病患者睡眠障碍的重视程度，并为改善慢性肝病患者的睡眠情况提供新思路。更多还原

【Abstract】 Chronic liver disease has gradually become one of the leading causes of death worldwide. Chronic liver diseases caused by various reasons are often accompanied by different degrees or types of sleep disorders, such as difficulty falling asleep, early awakening, dreaminess, daytime sleepiness, and day-night reversal. The main mechanisms of sleep disturbance in patients with chronic liver disease including circadian rhythm disturbance, hepatic encephalopathy, intestinal flora imbalance, etc. At the same time, more and more evidences show that sleep disorder will seriously affect the quality of daily life and disease prognosis of patients with liver disease. This article reviewed recent researches on the interaction between sleep disorders and chronic liver disease, in order to increase clinicians′ attention to sleep disorders in patients with liver disease, and to provide new ideas for improving sleep in patients with chronic liver disease.更多还原