【摘要】 目的 报告15例胃泌酸腺腺瘤的临床表现、病理及内镜特征，并复习相关文献。方法 回顾性分析2021年12月至2023年7月武汉市第一医院诊断为胃泌酸腺腺瘤15例患者的临床表现、内镜检查结果、组织病理学特点、治疗方式及随访情况。结果 15例胃泌酸腺腺瘤患者中，男6例，女9例，平均年龄54岁。病变部位多见于胃中上部，内镜下多为息肉样隆起表现，超声内镜显示为起源于黏膜层或黏膜肌层的高回声隆起病变。5例行ESD治疗，10例行EMR治疗。免疫组织化学检查提示CgA(-)、CD56(+)、Syn(弱+)、MUC6(+)。术后随访3～22个月无复发病例。结论 胃泌酸腺腺瘤好发于中老年女性，临床症状无明显特异性表现，内镜下难以与胃息肉相鉴别，确诊依赖于病理组织学检查。对该疾病的认识还有待于病例的进一步积累与总结。更多还原

【Abstract】 Objective To report the clinical, pathological and endoscopic features of 15 cases of gastric oxyntic gland adenoma, and review the relevant literature. Methods The clinical manifestations, endoscopic findings, histopathological features, treatment methods and follow-up of 15 patients diagnosed with gastric oxyntic gland adenoma in Wuhan First Hospital from Dec. 2021 to Jul. 2023 were retrospectively analyzed. Results Among the 15 patients with gastric oxyntic gland adenoma, there were 9 females and 6 males with an average age of 54 years old. The lesions were more common in the middle and upper part of the stomach, and they were mostly polypoid eminences under endoscopy, while endoscopic ultrasonography showed hyperechoic eminences originating from mucosal layer or mucosal myometria. Five patients were treated with ESD and 10 with EMR. Immunohistochemical examination showed CgA(-), CD56(+), Syn(weak+), MUC6(+). There were no recurrence cases after 3-22 months of follow-up. Conclusion Gastric oxyntic gland adenoma is most common in middle-aged and elderly women, and the clinical symptoms have no obvious specific manifestations, which is difficult to distinguish from gastric polyps under endoscopy. The diagnosis depends on histopathological examination. The understanding of this disease still needs to be further accumulated and summarized.更多还原