【摘要】 肝脏脂肪变性即肝内甘油三酯(intrahepatic triacylglycerol, IHTG)过量积累是非酒精性脂肪肝(nonalcoholic fatty liver, NAFLD)的标志，同样也是大多数肝病的重要诱因。IHTG含量与肝脏胰岛素敏感性密切相关，肝脏本身脂肪积累可能就是肝脏胰岛素作用受损的原因。运动作为预防和治疗多种慢性疾病的有效干预措施，可以促进短期和长期的全身代谢适应，肝脏对运动最显著适应就是IHTG的减少，即使没有观察到整体体重的减轻。因此，文章旨在阐明IHTG积累与肝脏胰岛素代谢之间的复杂关联，并强调运动调控IHTG积累对肝脏胰岛素代谢的重要性，这可能为代谢相关脂肪性肝病的治疗提供新靶点。更多还原

【Abstract】 Hepatic steatosis, characterized by excessive accumulation of intrahepatic triglycerides(IHTG),is a hallmark of nonalcoholic fatty liver disease(NAFLD) and a prerequisite for most liver diseases.IHTG is closely associated with hepatic insulin sensitivity.The deposition of lipids in the liver itself may contribute to the impairment of hepatic insulin action.As an effective intervention to prevent and treat various chronic diseases, exercise can promote short-term and long-term systemic metabolic adaptations.The most significant adaptation of the liver in response to exercise is the reduction of IHTG,even without overall weight loss.Therefore, this study aims to clarify the complex relationship between IHTG accumulation and hepatic insulin metabolism, and emphasize the importance of exercise in regulating IHTG accumulation and hepatic insulin metabolism, which may provide a novel target for the management of metabolism-related fatty liver disease.更多还原