【摘要】 人乳头瘤病毒(HPV)是引起宫颈上皮内瘤变和宫颈癌的重要原因之一，对机体影响较大的主要是高危型HPV16和18。当HPV感染机体后，为躲避体内各种先天和获得性免疫反应，病毒在感染的不同阶段分别进化出了许多免疫逃避的策略。其中HPV早期蛋白在调节宿主免疫反应方面起了非常重要的作用，病毒持续感染期间的免疫失调可能有助于免疫抑制，这是HPV相关癌症进展所必需的。该文就HPV E5、E6和E7蛋白通过抑制免疫系统，使病毒能够逃避宿主各种免疫防御的机制进行综述。更多还原

【Abstract】 Human papillomavirus(HPV)is one of the important risk factors of cervical intraepithelial neoplasia and cervical cancer.The high-risk types of HPV16 and 18 are the main types that have a greater impact on the body.Upon infecting the body, HPV has developed numerous immune escape strategies at different stages of infection to evade both innate and acquired immune responses.The HPV early protein plays a crucial role in regulating the host immune response during persistent infection, especially causing immunosuppression, which is essential for the progression of HPV-related cancers.This article reviews the mechanisms by which HPV early proteins, E5,E6 and E7,suppress the immune system and enable viruses to evade various immune defenses of the host.更多还原