【摘要】 弹性波光学相干弹性成像是利用波速定量获得生物组织弹性模量的方法，在医学研究与疾病诊断的领域具有重要应用价值．目前利用瑞利波理论评估一定厚度软材料的弹性模量存在较大的测量误差．为了提高弹性模量测量的准确度，提出了一种基于瑞利-兰姆方程反求弹性模量参数的方法．根据瑞利-兰姆方程的数值解，在确定仿体厚度的情况下，匹配合适的激励频率测量并获得弹性模量，将原位测试的弹性模量与拉伸实验结果进行比较，发现相对误差在3%以内．通过双层仿体的频散实验发现，在匹配的激励频率下，原位测量的弹性模量与拉伸实验测量的弹性模量几乎一致，结果表明该方法在测量上层仿体时不受下层仿体的影响．通过真实猪皮组织测量，结果表明该方法可以适用于皮肤组织测量．本研究提出的原位软材料光学相干弹性测量方法可以为生物组织的弹性定量表征提供更准确的测试手段．更多还原

【Abstract】 Elastic wave optical coherence elastography is a method that can quantitatively measure the elastic modulus of biological tissues by using wave velocity. It has an important application value in medical research and disease diagnosis. At present,several measurement errors occur in evaluating the elastic modulus of soft materials with a certain thickness using Rayleigh wave theory. To improve the accuracy of elastic modulus measurement,an inverse method of elastic modulus parameters based on the Rayleigh-Lamb equation is proposed. According to the numerical solution of the Rayleigh-Lamb equation,the elastic modulus was obtained by matching the appropriate excitation frequency under the condition that the thickness of the phantom was determined. The elastic modulus measured in situ was compared with the tensile experiment results,and the relative error was found to be within 3%. It is found that the elastic modulus measured in situ is almost the same as that measured by the tensile experiment under the matching excitation frequency,which demonstrates that the method is not affected by the lower layer when measuring the upper layer. The results of real pig-skin tissue measurement show that the method can be applied to skin tissue measurement. In this study,the optical coherence elastic measurement method of soft materials in situ provides a more accurate measurement method for the quantitative characterization of the elasticity of biological tissues.更多还原