【摘要】 目的：分析急性脑梗死（ACI）患者血压变异性与认知功能障碍的关系。方法：回顾性分析2018年6月至2021年6月福建医科大学附属南平第一医院收治的80例ACI患者的临床资料，按照蒙特利尔认知评估量表（MoCA）评分分为认知功能障碍组（评分<26分）、非认知功能障碍组（评分≥26分）。统计患者基线资料，分析ACI患者血压变异性指标[24 h舒张压变异系数（24h DCV）、24 h收缩压变异系数（24h SCV）、24 h舒张压标准差（24h DSD）、24 h收缩压标准差（24h SSD）]与认知功能障碍的关系。结果：80例ACI患者经MoCA量表评估，发生认知功能障碍31例，发生率为38.75%；多因素logistic回归分析结果显示，血压变异性指标均是ACI患者认知功能障碍的危险因素（OR均> 1,P均<0.05）；受试者工作曲线（ROC）结果显示，24h DCV、24h SCV、24h SSD、24h DSD水平预测ACI患者认知功能障碍发生的曲线下面积（AUC）均> 0.70，有一定预测价值，其中联合检测价值最高。结论：ACI患者的血压变异性与认知功能障碍的发生密切相关，能够有效预测认知功能障碍的发生。更多还原

【Abstract】 Objective To analyze the relationship between blood pressure variability and cognitive dysfunction in patients with acute cerebral infarction(ACI). Methods The clinical data of 80 patients with ACI admitted to the First Hospital of Nanping Affiliated to Fujian Medical University from June 2018 to June 2021 were retrospectively analyzed. They were divided into cognitive impairment group(score < 26) and non-cognitive impairment group(score ≥ 26) according to the Montreal Cognitive Assessment Scale(MoCA). The baseline data of patients were collected to analyze the relationship between the blood pressure variability index [24h diastolic blood pressure variability coefficient(24h DCV), 24 h systolic blood pressure variability coefficient(24h SCV), 24 h diastolic blood pressure standard deviation(24h DSD), 24 h systolic blood pressure standard deviation(24h SSD)] and cognitive impairment in ACI patients. Results Among 80 patients with ACI, 31 patients had cognitive impairment, the incidence was 38.75%; Multivariate logistic regression analysis showed that blood pressure variability indicators were risk factors for cognitive dysfunction in patients with ACI(OR > 1, P < 0.05); The results of the subject working curve(ROC) showed that the area under the curve(AUC) of 24h DCV, 24h SCV, 24h SSD, 24h DSD levels predicting the occurrence of cognitive dysfunction in patients with ACI was more than 0.70, which had a certain predictive value, of which the joint detection value was the highest. Conclusion The blood pressure variability of ACI patients is closely related to the occurrence of cognitive dysfunction, which can effectively predict the occurrence of cognitive dysfunction.更多还原