【摘要】 2型糖尿病是患病率较高的内分泌系统疾病；慢性牙周炎是发病率较高的口腔常见病。多项研究表明两者在临床症状上密切相关。近几年学者通过微生物层面的实验，逐渐揭示2型糖尿病、慢性牙周炎患者的口腔菌群情况，试图探索2型糖尿病伴慢性牙周炎患者的疾病规律，但是尚未有文献对2型糖尿病伴慢性牙周炎患者口腔菌群的多样性、特异性作一系统介绍。本文从2型糖尿病与慢性牙周炎的临床关联性入手，阐述二者与口腔菌群的关系，依据微生物学迅速发展更新的实验方法，对2型糖尿病伴慢性牙周炎患者的口腔菌群微环境研究进展进行综述，旨为后续深入研究指明方向。更多还原

【Abstract】 Type 2 diabetes mellitus(T2DM)is an endocrine disease with high prevalence,and chronic periodontitis(CP)is a common oral disease with high incidence. A number of studies have shown that the two are closely related in clinical manifestations. In recent years,researchers have gradually revealed the status of oral microbiota in patients with T2DM and CP through experiments at the microbial level,trying to explore the law of disease in patients with T2DM and CP. However,there is no systematic introduction to the diversity and specificity of oral microbiota in patients with T2DM and CP. Based on the clinical correlation,this article elaborates the relationship between the two diseases and oral microbiota,and further reviews the research progress of the oral microenvironment of T2DM patients with CP according to the rapid development and update of experimental methods in microbiology,so as to provide the direction for further research.更多还原