【摘要】 目的 应用彩色多普勒血流显像（CDFI）检测2型糖尿病早期视网膜病变（DR）视网膜中央动脉（CRA）血流动力学的异常变化，探讨CDFI对DR患者的诊断价值。方法 选取河南省洛阳市第一人民医院2型非糖尿病视网膜病变（NDR）患者33例（33只眼），非增殖性糖尿病视网膜病变（NPDR）患者38例（38只眼），应用CDFI检测2组患者视网膜中央动脉的血流参数：收缩期血流速度（PSV），舒张末期血流速度（EDV）及阻力指数（RI），对其结果进行对照分析。结果 2组患者视网膜中央动脉的各项血流参数比较差异均具有统计学意义，PSV(t=3.261,P<0.05),EDV(t=4.948,P<0.01),RI(t=5.823,P<0.01);ROC曲线分析结果显示PSV、EDV及RI曲线下面积（AUC）均>0.70。结论 通过CDFI检测2型糖尿病患者视网膜中央动脉血流参数异常变化的规律，可为DR提供定量诊断，为临床早防早治提供可靠依据。更多还原

【Abstract】 Objective To detect abnormal changes of central retinal artery(CRA) hemodynamics in patients with early retinopathy(DR) in type 2 diabetes by using color Doppler flow imaging, and explore the diagnostic value of color Doppler flow imaging in type 2 diabetes patients with early retinopathy. Methods Thirty-three cases(33 eyes) of type 2 diabetes patients with no retinopathy(NDR) and 38 cases(38 eyes) of diabetes patients with non-proliferative retinopathy(NPDR) were selected. The blood flow parameters of the central retinal artery in the two groups of patients were measured by color Doppler blood flow(imaging),and compared systolic blood flow velocity(PSV), end diastolic blood flow velocity(EDV) and resistance index(RI). The results were compared and analyzed. Results The various blood flow parameters of the central retinal artery between the two groups of patients were statistically significant, PSV(t=3.261, P<0.05), EDV(t=4.948,P<0.01), RI(t=5.823,P<0.01). The ROC analysis results show that the area under the PSV, EDV and RI curves(AUC) are more than0.70. Conclusion Detecting abnormal changes of central retinal artery blood flow parameters in patients with type2 diabetes by color Doppler flow imaging can provide quantitative diagnosis for early retinopathy in type 2diabetes and reliable basis for clinical early prevention and treatment.更多还原