【摘要】 血管性痴呆(VD)是由脑血管疾病所致脑供血减少导致的进行性认知障碍性综合征,其发病率仅次于阿尔茨海默病(AD)。我国VD的患病率为1.1%～3.0%,患者人数在全球患痴呆人数中高达20%。患者会产生记忆的缺失、认知功能障碍等症状,以至于丧失生活自理能力,给其家庭及社会带来极大负担。随着人口老龄化以及患者数量增多、治疗费用的增高,如何应对以上因素导致的VD已成为世界面对的公共卫生问题。目前其发病机制尚不明确,还没有非常有效的治疗手段。作为唯一可以预防的痴呆类型,如何防治VD,成为临床研究的重点和难点。生物标志物可以体现病情治疗过程中的某种特征,相关生物标志物对于VD的早期诊断、发病机制、指导治疗策略、预后评估等方面具有重要作用。长期服用西药会产生耐药性、依赖性等多种不良反应,因此许多研究在传统中医理论的基础上,将针刺与中药方剂、西医药物相结合,根据患者个人体质、基本病情选穴配方,旨在改善患者病情,均取得了良好的临床效果。本文从中国期刊全文数据库(CNKI)检索了近5年关于VD针灸研究的相关文献,发现许多与VD相关的生物标志物,按照其分子类别进行分类,从其对VD诊疗的应用价值,以其为靶点的针刺干预作用以及特殊针刺方法这3个方面进行归纳评述,为VD的治疗及研究提供一定的思路。更多还原

【Abstract】 Vascular dementia(VD)is a progressive cognitive disability syndrome caused by reduced blood supply to the brain caused by cerebrovascular diseases,and its incidence is second only to Alzheimer’s disease(AD).The prevalence rate of VD in China ranges from 1.1%-3.0%,and the number of patients with dementia is as high as 20% of the global population.Patients suffer from memory loss,cognitive dysfunction and other symptoms,so that they lose the ability to take care of themselves,which places a great burden to their families and society.With the aging of population,the increasing number of patients and the increasing cost of treatment,how to deal with VD caused by the above factors has become a public health problem facing the world.At present,the pathogenesis is not clear,and there is no effective treatment,as the only type of dementia that can be prevented,how to prevent VD has become the focus and difficulty of clinical research.Biomarkers reflect certain characteristics in the course of disease treatment,and related biomarkers play an important role in the early diagnosis,pathogenesis,guidance of treatment strategies,prognosis assessment and other aspects of VD.Long-term use of Western medicine will produce a variety of adverse effects such as drug resistance and dependence.Therefore,many studies have combined acupuncture with Chinese herbal formulas and western drugs on the basis of traditional Chinese medicine theory,and selected acupuncture point formulas according to the patient’s individual constitution and the underlying condition,all of which have achieved good clinical effects.In this paper,the literature related to VD acupuncture research in the past 5 years was retrieved from the China Journal Full-text Database(CNKI).Many biomarkers related to vascular dementia were found and classified according to their molecular categories.This paper summarized and commented on the application value of VD in the diagnosis and treatment of vascular dementia,the intervention effect of targeted acupuncture and special acupuncture methods,which provided certain ideas for the treatment and research of VD.更多还原