【摘要】 疾病修饰治疗是帕金森病（PD）未被满足的临床需求。随着对发病机制研究的深入，新的靶点为帕金森病疾病修饰治疗带来希望。选择生物标志物驱动的PD亚型、合适的疾病分期，制定精准治疗策略，使用更优化的研究方案应该能够增加疾病修饰治疗成功的可能。更多还原

【Abstract】 Disease modification therapy is an unmet clinical need for Parkinson disease(PD). With the progress of research in the pathogenesis of PD,new targets bring hope for disease moditication therapy. The use of objective biomarkers drivensubtypes of PD,appropriate disease stages,precise treatment strategies,and optimized protocols should increase the likelihood of successful disease-modification therapy.更多还原