【摘要】 目的 分析呼出气一氧化氮（FeNO）、尘螨皮肤点刺试验（SPT）结果对呼吸道症状特应症患者气道高反应的预测价值。方法 回顾性分析2021年2月至2023年3月于贵州省人民医院呼吸内科门诊就诊的136例伴有呼吸道症状特应症患者的临床资料，根据支气管激发试验结果分为支气管激发试验阳性组（41例）和阴性组（95例），比较两组FeNO、SPT指标的差异，采用受试者工作特征曲线（ROC）分析FeNO与SPT对支气管激发试验结果的预测价值。结果支气管激发试验阳性组的FeNO值明显高于阴性组，SPT（++++）比例高于SPT（+）和SPT（++），差异有统计学意义（P<0.05）。ROC曲线显示，Fe NO诊断气道高反应的最佳界值为35.5×10^-9mol/L，灵敏度39.0%，特异度83.2%,ROC曲线下面积（AUC）0.811;SPT诊断气道高反应的最佳界值为++++，灵敏度75.6%，特异度78.9%,AUC 0.650;FeNO联合SPT检测，灵敏度80.5%，特异度74.7%,AUC 0.821。结论 呼吸道症状特应症患者的FeNO值对于气道高反应性有一定的预测作用。当Fe NO>35.5×10^-9mol/L时预测支气管激发试验阳性的准确性较高，提示患者存在气道高反应性。FeNO联合SPT后，敏感度和AUC增加。更多还原

【Abstract】 Objective To analyze the predictive value of fractional exhaled nitric oxide（FeNO）and dust mite skin prick test（SPT）for airway hyperresponsiveness in patients with atopic respiratory symptoms. Methods A retrospective analysis was conducted on the clinical data of 136 patients with atopic respiratory symptoms who visited the Respiratory Department of Guizhou Provincial People′s Hospital from February 2021 to March 2023. Based on the results of bronchial provocation tests,patients were divided into the positive group（n=41）and the negative group（n=95） to explore the differences in FeNO and SPT between the 2 groups. The predictive value of FeNO and SPT for bronchial excitation test was analyzed by receiver operating characteristic curve（ROC）.Results The FeNO value in the positive group of bronchial provocation test was significantly higher than that in the negative group,and SPT（++++）ratio was higher than SPT（+）and SPT（++）,the difference being statistically significant（P<0.05）. The ROC curve showed that cut off value for diagnosing bronchial provocation test with FeNO was 35.5×10^-9mol/L,with sensitivity being 39.0%,specificity being 83.2%,and area under the ROC curve（AUC）was 0.811; the cut-off value for diagnosis of bronchial provocation test by SPT was SPT（++++）,with sensitivity being 75.6%,specificity being 78.9%,and AUC was0.650; FeNO combined with SPT detection showed a sensitivity of 80.5%and specificity was 74.7%,and AUC was 0.821.Conclusion The FeNO value of patients with respiratory symptom atopy has a certain predictive value on BPT. When FeNO>35.5×10^-9mol/L,the accuracy of predicting positive BPT is higher,indicating the presence of BHR in patients.When FeNO combines with SPT,the sensitivity and AUC increase,improving the diagnostic value.更多还原