【摘要】 目的 分析胆囊隆起性病变超声造影特征与临床病理学特点的相关性。方法 回顾性选取2019年7月至2022年7月克拉玛依市中心医院收治的疑似胆囊隆起样病变患者60例作为研究对象。所有患者均进行超声造影检查，以病理诊断结果为金标准，分析超声造影特征及超声造影对胆囊隆起性病变的诊断价值。采用Pearson检验分析临床病理学特点、超声造影特征与胆囊隆起样病变之间的相关性。采用多因素Logistic回归分析影响胆囊隆起样病变形成的独立危险因素。结果 胆囊隆起性病变在增强程度、动脉期血管分型方面差异有统计学意义(P<0.05)。经一致性分析证实，超声造影评估胆囊隆起性病变的敏感度为96.43%,特异度为87.50%,准确率为91.67%,阳性预测值为87.10%,阴性预测值为96.55%,Kappa值为0.728。胆囊隆起性病变直径≤10 mm者占41.67%(25/60),显著高于胆囊隆起性病变直径>10 mm者[8.33%(5/60)],差异有统计学意义(P<0.05)。Pearson相关性检验显示，超声造影增强程度、动脉期血管分型为点状型、分支血管型、病变直径与胆囊隆起性病变形成均呈正相关(r=0.714、0.726、0.733、0.726,P<0.05)。多因素Logistic回归分析结果显示，超声造影增强程度、动脉期血管分型为点状型、分支血管型、病变直径是胆囊隆起性病变形成的独立危险因素(P<0.05)。结论 超声造影增强程度、动脉期血管分型为点状型、分支血管型，病变直径是胆囊隆起性病变形成的独立危险因素，可作为胆囊隆起性病变形成的提示因素，值得在临床上应用。更多还原

【Abstract】 Objective To analyze the correlation between ultrasonographic features and clinicopathological characteristics of gallbladder augmentation lesions. Methods Sixty patients with suspected gallbladder augmentation-like lesions admitted to Karamay Central Hospital from July 2019 to July 2022 were retrospectively selected as the study subjects. All patients underwent ultrasonography, and pathological diagnostic findings were used as the gold standard. The contrast features of ultrasonography were analyzed. The diagnostic value of ultrasonography for gallbladder augmentation lesions was compared. The Pearson test was used to analyze the correlation between clinicopathological features, ultrasonographic features and gallbladder augmentation-like lesions. Multifactorial logistic regression was used to analyze the independent risk factors affecting the formation of gallbladder augmentation-like lesions. Results There was a statistically significant difference in the degree of enhancement and arterial phase vascular classification of gallbladder protrusion lesions(P<0.05). After consistency analysis, it was confirmed that the sensitivity, specificity, accuracy, positive predictive value, negative predictive value, and Kappa value of contrast-enhanced ultrasound in evaluating gallbladder protrusion lesions were 96.43%, 87.50%, 91.67%, 87.10%, 96.55%, and 0.728, respectively. The proportion of patients with gallbladder protrusion lesions with a diameter ≤10 mm was 41.67%(25/60), which was significantly higher than those with gallbladder protrusion lesions with a diameter>10 mm [8.33%(5/60)], and the difference was statistically significant(P<0.05). Pearson correlation test showed that the degree of ultrasonographic enhancement, arterial phase vascular typing as punctate, branching vascular type, and lesion diameter were positively correlated with gallbladder augmentation lesion formation(r=0.714, 0.726, 0.733, 0.726; P<0.05). Multifactorial Logistic regression analysis showed that the degree of ultrasonographic enhancement, arterial phase vascular typing as punctate, branching vascular type, and lesion diameter were independent risk factors for gallbladder augmentation lesion formation(P<0.05). Conclusion The degree of ultrasonographic enhancement, arterial phase vascular typing as punctate and branching vascular type, and lesion diameter are independent risk factors for the formation of gallbladder augmentation lesions, which can be used as suggestive factors for the formation of gallbladder augmentation lesions and are worthy of clinical application.更多还原