【摘要】 目的 探讨益气温阳、活血利水法对慢性心力衰竭(CHF)患者心功能及神经内分泌相关指标的影响。方法 前瞻性选取2021年1月至2022年1月期间在黑龙江中医药大学附属第一医院就诊90例CHF患者为研究对象，随机数字表法分为研究组与对照组，每组各45例。两组均予以常规西药治疗，研究组在此基础上采用益气温阳、活血利水法进行治疗。观察比较两组患者治疗前后的心功能及神经内分泌相关指标变化情况。结果 治疗前，两组左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)以及左室射血分数(LVEF)比较，差异均无统计学意义(P>0.05);治疗后，研究组的LVESD、LVEDD分别为(45.33±5.94)、(42.68±5.87) mm,均明显低于对照组[(52.93±6.11)、(50.06±5.33) mm],LVEF为(48.16±5.93)%,明显高于对照组[(39.52±5.22)%],差异均有统计意义(P<0.05)。治疗前，两组B型钠尿肽原(BNP)、肾素活性、醛固酮、AngⅡ比较，差异均无统计学意义(P>0.05);治疗后，研究组的BNP、肾素活性、醛固酮、AngⅡ为(240.36±32.18)pg/mL、(2.58±0.47)ng/(mL·h)、(201.26±25.13)pg/mL、(70.23±8.24)pg/mL,均明显低于对照组[(392.13±33.54)pg/mL、(3.89±0.54)ng/(mL·h)、(268.44±26.89)pg/mL、(98.65±9.32)pg/mL],差异均有统计意义(P<0.05)。结论 益气温阳、活血利水法治疗CHF疗效确切，能够显著改善患者的心功能，降低神经内分泌相关指标，值得推广。更多还原

【Abstract】 Objective To investigate the effect of Yiqiwenyang and Huoxue Lishui Recipe on cardiac function and neuroendocrine related indexes in patients with chronic heart failure(CHF). Methods A total of 90 patients with CHF admitted to the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from January 2021 to January 2022 were selected as research subjects and divided into study group and control group according to the random number table method, with 45 cases in each group. Both groups were treated with conventional western medicine. On this basis, the study group was treated with Yiqiwenyang and Huoxue Lishui Recipe, and the changes of cardiac function and neuroendocrine related indexes were observed and compared between the two groups before and after treatment. Results Before treatment, there was no statistically significant difference in left ventricular end systolic diameter(LVESD), left ventricular end diastolic diameter(LVEDD), and left ventricular ejection fraction(LVEF) between the two groups(P>0.05); after treatment, LVESD and LVEDD in the study group were(45.33±5.94),(42.68±5.87) mm, which were significantly lower than those in the control group [(52.93±6.11),(50.06±5.33) mm], LVEF was(48.16±5.93)%, which was significantly higher than that in the control group [(39.52±5.22)%], and the difference was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in type B natriuretic peptidogen(BNP), PRA, ALD, Ang Ⅱ between the two groups(P>0.05); after treatment, BNP, PRA, ALD and Ang Ⅱ in the study group were(240.36±32.18) pg/mL,(2.58±0.47) ng/(mL·h),(201.26±25.13) pg/mL,(70.23±8.24) pg/mL, which were significantly lower than those in the control group [(392.13±33.54) pg/mL,(3.89±0.54) ng/(mL·h),(268.44±26.89) pg/mL,(98.65±9.32) pg/mL], the differences were statistically significant(P<0.05). Conclusion The treatment of CHF with Yiqiwenyang and Huoxue Lishui Recipe is effective, can significantly improve the heart function of patients, reduce neuroendocrine related indicators, worthy of promotion.更多还原