【摘要】 目的 ：了解普陀区早死风险人群和筛查推荐人群结直肠癌发病和死亡率的变化趋势差异，为切实降低结直肠癌发病、死亡水平，完善辖区结直肠癌筛查方案提供参考。方法 ：收集2004-2019年普陀区户籍居民结直肠癌发病和死亡信息，分别计算早死风险年龄段30～69岁和筛查推荐的50～74岁年龄段结直肠癌发病率和死亡率及相应的标率，并用年度变化百分比（APC）反映率的变化趋势。结果 ：2004-2019年普陀区早死风险人群和筛查推荐人群的结直肠癌粗发病率和标化发病率均在上升，标化死亡率均呈下降趋势；早死风险人群的粗死亡率有上升（均P <0.05）。男性早死风险人群和筛查推荐人群的粗发病率、标化发病率均上升（P <0.05）。女性早死风险人群粗发病率有上升，标化死亡率下降（均P <0.01）；男性两类人群发病率、死亡率增速均高于同类女性。结论 ：普陀区早死风险人群粗发病率、粗死亡率增速较快，男性两类人群发病和死亡水平及增速均高于同类女性。建议进一步完善结直肠癌筛查方案，适当拓展筛查年龄范围，惠及早死风险人群。针对男性制定更具效力的健康促进和筛查策略，提高筛查比例及治疗管理质量，促进辖区结直肠癌发病、死亡水平全面下降。更多还原

【Abstract】 Objective: To understand the differences of the change trend of incidence and mortality of colorectal cancer(CRC)between the population at risk of premature death and the population recommended for screening, so as to provide reference for reducing the incidence and mortality of CRC and improving the screening program of CRC in Putuo District. Methods: The information of incidence and mortality of CRC among permanent residents in Putuo District from 2004 to 2019 were collected to calculate the morbidity and mortality rates of CRC, and corresponding standard rates in the population of 30-69 years old and the recommended 50-74 years old groups, and the annual percentage change(APC) was used to reflect the change trend. Results: From 2004 to 2019,the crude morbidity and standardized rates of CRC in the population at risk of premature death and the population recommended for screening in Putuo District increased, while the standardized mortality decreased; the crude death rate in the population of premature death increased(P<0.05), Both crude morbidity rates and standardized incidence rates in the population at risk of premature death and the population recommended for screening in the male increased(P<0.05). The crude morbidity in female population at risk of premature death increased(P<0.01), while the standardized mortality rate decreased(P<0.01); the increasing rates of morbidity and mortality in males in the two groups were higher than those in females. Conclusion: The crude morbidity and standardized rates of CRC in the population at premature death in Putuo District increase faster, the incidence, mortality level and growth rate in the males in the two groups were higher than those in the females in the similar groups. It is recommended to further perfect the CRC screening program, and appropriately expand the screening age range, so as to benefit the population at risk of premature death. More effective health promotion and screening strategies should be developed for the males to improve the screening rate and the quality of treatment and management,so as to promote the overall reduction of CRC incidence and mortality levels in Putuo District.更多还原