【摘要】 目的:探讨¹⁸F-FDG PET/CT显像代谢参数与非小细胞肺癌（non-small cell lung cancer, NSCLC）原发灶程序性细胞死亡配体1（programmed cell death-ligand 1,PD-L1）表达水平的关系。方法:回顾性分析56例经病理证实的非小细胞肺癌患者的临床病理资料及治疗前¹⁸F-FDG PET/CT影像，所有患者均使用免疫组化法检测PD-L1表达状态，分析¹⁸F-FDG PET/CT的代谢参数与原发灶PD-L1表达水平的相关性。结果:与PD-L1阴性患者比较，阳性患者原发灶SUV_max、MTV、TLG均较高（P<0.05）。通过Spearman相关性分析，PD-L1的表达与SUV_max、MTV、TLG均有显著的相关性（r=0.537,P=0.000;r=0.413,P=0.002;r=0.457,P=0.000）。经多变量分析，SUV_max被确定为预测肿瘤PD-L1表达的唯一独立因素（OR:2.132,95%CI:1.694～2.578,P=0.006）。结论:非小细胞肺癌原发灶FDG摄取与PD-L1表达存在相关性，PD-L1阳性更易发生在高SUV_max、MTV和TLG患者中。更多还原

【Abstract】 Objective:To investigate the relationship between programmed cell death-ligand 1（PD-L1）expression and metabolic parameters of fluorine-18 fluorodeoxyglucose（FDG） PET/CT imaging in non-small cell lung cancer（NSCLC）.Methods:The clinicopathological data and ¹⁸F-FDG PET/CT images before treatment were retrospectively analyzed in 56 patients pathologically proved NSCLC.Immunohistochemistry detected PD-L1 expression.The correlation between ¹⁸F-FDG PET/CT metablic parameters and PD-L1 expression level in primary focus was analyzed.Results:Compared with patients with negative PD-L1,the SUV_max,MTV,TLG of primary focus in patients with positive PD-L1 were higher（P<0.05）.Spearman correlation analysis showed PD-L1 expression was correlated with maximum standardized uptake value(SUV_max),metabolic tumor volume（MTV）,total lesion glycolysis（TLG）（r=0.537,P=0.000;r=0.413,P=0.002;r=0.457,P=0.000）.Multivariate analysis showed SUV_max was a unique independent predictor of tumor PD-L1 expression（OR:2.132,95%CI:1.694～2.578,P=0.006）.Conclusion:There was a correlation between FDG uptake and PD-L1 expression in primary focus of NSCLC.The positive PD-L1 were more likely to occur in patients with high SUV_max,MTV and TLG.更多还原