【摘要】 胰腺癌肿瘤微环境中癌相关成纤维细胞(cancer-associated fibroblasts, CAFs)具有促进胰腺癌组织增殖、侵袭、转移、血管生成、免疫抑制及耐药等作用，在胰腺癌的演变和进展中发挥了重要作用。由于CAFs的起源较多且具有表型和功能异质性，给靶向CAFs的抗肿瘤治疗带来了巨大挑战，但是探究CAFs与胰腺癌细胞的相互作用可以为日后靶向CAFs治疗胰腺癌提供帮助。本文将探究胰腺癌肿瘤微环境中CAFs的作用机制并对近些年来国内外有关CAFs对胰腺癌作用的相关文献进行综述。更多还原

【Abstract】 CAFs can promote the proliferation, invasion, metastasis, angiogenesis, immunosuppression and drug resistance in pancreatic cancer microenvironment, and play an important role in the evolution and progression of pancreatic cancer.Due to the multiple origins, phenotypic and functional heterogeneity of CAFs, anti-tumor therapy targeting CAFs presents great challenges.However, exploring the interaction between CAFs and pancreatic cancer cells can provide help for future CAFs targeted treatment of pancreatic cancer.To explore the mechanism of CAFs in pancreatic cancer microenvironment.The literatures about the effect of CAFs on pancreatic cancer in recent years were reviewed.更多还原