【摘要】 本文首先利用中药系统药理学数据库分析平台TCMSP构建连翘成分-疾病靶点网络及靶蛋白互作网络，采用R语言包进行生物功能（GO）和通路（KEGG）富集分析，再根据网络药理学结果，结合文献资料，采用SYBYL 2.1.1进行分子对接，分析连翘活性成分与胆汁酸调节通路关键靶点的相互作用。网络药理学筛选得到活性成分17个，核心靶点8个，主要涉及胆汁酸代谢转运、核受体反馈调控、胆红素转化、炎症氧化损伤的细胞应答等，分子对接显示这些连翘活性成分与核受体有较好结合，木脂素类可能是连翘抗胆汁淤积的主要活性成分群。连翘显示出通过多成分、多靶点、多途径方式作用于胆汁淤积关键靶标的潜力，通过核受体调控胆汁酸代谢、抗炎抗氧化损伤等可能是其抗胆汁淤积的主要机制，这为连翘治疗肝胆疾病的研究和开发提供了依据和参考。更多还原

【Abstract】 In this paper, we used Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP) to construct the components of Forsythia suspensa-disease targets network and target protein interaction network. R package was used for enrichment analysis of biological functions(GO) and pathways(KEGG). Then, based on the results of network pharmacology and combined with the literature, SYBYL 2.1.1 was selected for molecular docking to analyze the interaction of active components of Forsythia suspensa with key targets of the bile acid regulatory pathway. Network pharmacology screening yielded 17 active ingredients and 8 core targets mainly involving bile acid metabolic transport, nuclear receptor feedback regulation, bilirubin conversion, cellular response to inflammatory oxidative damage, etc. Molecular docking showed that these active components bind well to nuclear receptors, and lignans may be the main group of active components in the anti-cholestasis of Forsythia suspensa. Forsythia suspensa has shown the potential to act on key targets of cholestasis in a multi-component, multi-target and multi-pathway manner,and the regulation of bile acid metabolism through nuclear receptors, anti-inflammatory and antioxidant damage may be its main mechanism of anti-cholestasis. This provides a basis and reference for the research and development of Forsythia suspensa for the treatment of hepatobiliary diseases.更多还原