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厚朴酚的药理作用研究现状

Research Status of Pharmacological Action of Magnolol

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【作者】 贾音任晨曦夏悠楠王丹

【Author】 JIA Yin;REN Chenxi;XIA Younan;WANG Dan;Chronic Diseases Research Center, Medical College of Dalian University;

【通讯作者】 王丹;

【机构】 大连大学医学院慢性病研究中心

【摘要】 厚朴酚是一种应用广泛的中药单体,药用价值大,对机体的保护作用涉及多个方面。研究表明厚朴酚具有抑制炎症反应与氧化应激,抑制癌细胞增殖转移,破坏细菌毒性,改善维持肠黏膜功能,减轻肝损伤,缓解心肌纤维化以及保护神经等功效。本文通过总结近5年的文献,重新梳理了厚朴酚的抗炎、抗氧化、抑菌、抗肿瘤以及神经抑制等药理作用,在概述过程中更关注厚朴酚药理作用靶点和分子机制方面的研究进展,为厚朴酚的进一步开发和靶向治疗提供全面性的综述资料。

【Abstract】 Magnolol is a widely used monomer of traditional Chinese medicine, which has great medicinal value and many protective effects on the body. Studies have shown that magnolol can inhibit inflammatory reaction and oxidative stress, inhibit the proliferation and metastasis of cancer cells, destroy bacterial toxicity, improve the maintenance of intestinal mucosal function, reduce liver injury, alleviate myocardial fibrosis, protect nerves and so on. In this paper, the pharmacological effects of honokiol such as anti-inflammatory, anti-oxidation, bacteriostasis, anti-tumor and nerve inhibition are reviewed by summarizing the literature in the past five years. In the process of review, more attention is paid to the research progress in the pharmacological target and molecular mechanism of magnolol, providing comprehensive review data for the further development and targeted treatment of magnolol.

【关键词】 厚朴酚药理作用机制研究进展
【Key words】 magnololpharmacological actionmechanismresearch progress
  • 【文献出处】 生物化工 ,Biological Chemical Engineering , 编辑部邮箱 ,2023年03期
  • 【分类号】R285
  • 【下载频次】23
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