【摘要】 目的 探讨三氧自体血回输联合脉冲射频调节对带状疱疹后神经痛的治疗效果。方法 选取2018-08-01-2019-09-01青岛大学附属泰安市中心医院疼痛科收治的83例带状疱疹后神经痛患者为研究对象，根据其治疗方案分为基础治疗组(对照组，n=36)和三氧自体血回输组(三氧组，n=47)。对照组采用口服加巴喷丁胶囊、氨酚双氢可待因、度洛西汀肠溶片，并行椎旁神经脉冲射频治疗，1次/周，共2次；三氧组在对照组基础上，给予25μg/mL三氧自体血回输，1次/d,共5次。分别记录2组患者治疗前和治疗后1、3、6个月视觉模拟评分(VAS)及简明疼痛量表(BPI)评分，治疗后6个月疼痛缓解率以及加巴喷丁用量，治疗过程中的不良反应。结果 2组患者治疗后1、3、6个月VAS及BPI评分与治疗前相比均下降，三氧组较对照组下降更明显，差异有统计学意义，均P<0.01。三氧组治疗后6个月疼痛缓解有效率为97.87%,优于对照组的86.11%,但经Fisher精确概率法检验，2组之间差异无统计学意义，P=0.081。三氧组治疗后6个月加巴喷丁日用量为(434.0±248.7) mg,较对照组的(658.3±276.1) mg少，差异有统计学意义，t=3.882,P<0.001。三氧组行自体血回输中，有2例患者出现头晕，休息及进食后缓解，后续未再出现不适。结论 三氧自体血回输联合脉冲射频调节可以显著减轻患者的疼痛、降低止痛药物的用量，改善患者的生活质量，且不良反应少，安全性高。更多还原

【Abstract】 Objective To observe the clinical effect of trioxide autologous blood transfusion combined with pulse radiofrequency modulation on postherpetic neuralgia. Methods Totally 83 patients with postherpetic neuralgia admitted to the Pain Department of Taian Central Hospital Affiliated to Qingdao University from August 1, 2018 to September 1, 2019 were selected as the study subjects. They were divided into a basic treatment group(control group, n=36) and a trioxide autologous blood transfusion group(trioxide group, n=47) based on their treatment plans. The control group was treated with oral gabapentin capsules, aminophene dihydrocodeine, and duloxetine enteric coated tablets, and paravertebral nerve pulse radiofrequency therapy, once per week, twice in total; On the basis of the control group, the trioxide group was given 25 μg/ml autologous blood transfusion, once a day, a total of 5 times. We recorded the visual analogue scale(VAS) and brief pain inventory(BPI) scores of two groups of patients before and at 1, 3, and 6 months after treatment, the pain relief rate and gabapentin dosage at 6 months after treatment, as well as adverse reactions during the treatment process. Results After 1, 3, and 6 months of treatment, the VAS and BPI scores of the two groups of patients decreased compared to those before treatment, and the decrease in the trioxide group was more significant compared to the control group, with a statistically significant difference(P<0.01). The effective rate of pain relief in the trioxide group after 6 months of treatment was 97.87%, which was better than that of the control group 86.11%. However, according to Fisher’s exact probability test, there was no statistically significant difference between the two groups, P=0.081. The daily dosage of gabapentin in the trioxide group after 6 months of treatment was(434.0±248.7) mg, which was lower than that of the control group(658.3±276.1) mg, with a statistically significant difference(t=3.882, P<0.001).Two patients experienced dizziness in the trioxide group at time of autologous blood transfusion,and relieved after rest and having some food,and no further discomfort occurred thereafter.Conclusion The combination of autologous blood transfusion with pulse radiofrequency can significantly reduce patients’ pain,reduce the dosage of painkillers,improve their quality of life,and have fewer adverse reactions and high safety.更多还原