【摘要】 目的 探讨血液中中性粒细胞淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)及全身免疫炎症指数(SII)与腺样体肥大患儿腺样体肥大程度的关系。方法 选取2020年2月—2021年2月就诊于我院耳鼻咽喉头颈外科，经电子纤维喉镜确诊为腺样体肥大患儿181例。根据腺样体肥大分型及分度将患儿分为病理性腺样体肥大(Ⅲ～Ⅳ度肥大)组和生理性腺样体肥大(Ⅰ～Ⅱ度肥大)组(A组),进一步将病理性腺样体肥大组患儿分为Ⅲ度肥大组(B组)和Ⅳ度肥大组(C组)。比较各组间血浆NLR、PLR、SII差异，并分析上述指标对患儿腺样体肥大程度的影响。结果 三组患儿间血浆NLR及SII比较差异有显著性(F=27.346、22.533,P<0.001),血浆PLR水平比较则无显著差异(P>0.05),C组患儿血浆NLR、SII显著高于A、B组(P<0.05),B组患儿血浆NLR、SII显著高于A组(P<0.05)。ROC曲线显示血浆NLR、SII诊断病理性腺样体肥大曲线下面积分别为0.809和0.763,NLR诊断病理性腺样体肥大的灵敏度、特异度分别为93.85%和52.94%,SII诊断的灵敏度、特异度分别为42.31%和98.04%;当血浆NLR≥0.57和(或)SII≥356.41时，提示病理性腺样体肥大(Ⅲ度及以上肥大)可能性较大。结论血浆NLR和SII与儿童腺样体肥大程度具有相关性，且可作为初步预测病理性腺样体肥大的简易参考指标。更多还原

【Abstract】 Objective To investigate the association of neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), and systemic immune-inflammation index(SII) with the degree of adenoid hypertrophy in children. Methods This study was conducted for 181 children who attended Department of Otorhinolaryngology & Head and Neck Surgery in our hospital and were diagnosed with adenoid hypertrophy by fibrolaryngoscopy from February 2020 to February 2021. According to the type and degree of adenoid hypertrophy, the children were divided into pathological adenoid hypertrophy(degree Ⅲ-Ⅳ hypertrophy) group and physiological adenoid hypertrophy(degree Ⅰ-Ⅱhypertrophy) group(group A), and the pathological adenoid hypertrophy group was further divided into degree Ⅲ hypertrophy group(group B) and degree Ⅳ hypertrophy group(group C). Plasma NLR, PLR, and SII were compared between the above groups, and the influence of these indices on the degree of adenoid hypertrophy in children were analyzed. Results There were significant differences in plasma NLR and SII between the three groups(F=27.346, 22.533,P<0.001), while there was no significant difference in plasma PLR between the three groups(P>0.05); group C had significantly higher plasma NLR and SII than groups A and B(P<0.05), and group B had significantly higher plasma NLR and SII than group A(P<0.05). The receiver operating characteristic(ROC) curve analysis showed that plasma NLR and SII had an area under the ROC curve of 0.809 and 0.763, respectively, in the diagnosis of pathological adenoid hypertrophy, and NLR had a sensitivity of 93.85% and a specificity of 52.94%, while SII had a sensitivity of 42.31% and a specificity of 98.04%. Plasma NLR ≥0.57 and/or SII ≥356.41 might suggest the possibility of pathological adenoid hypertrophy(degree Ⅲ or above). Conclusion Plasma NLR and SII are correlated with the degree of adenoid hypertrophy in children and can thus be used as simple refe-rence indices for predicting pathological adenoid hypertrophy.更多还原