【摘要】 淋巴细胞活化基因-3 (LAG-3)是继程序性死亡受体-1 (PD-1)和细胞毒性T淋巴细胞相关蛋白4(CTLA-4)之后的又一热门免疫检查点，LAG-3能通过多种途径调节免疫系统功能，如LAG-3可调节T细胞的耗竭、活化和肿瘤识别杀伤能力，调节Treg细胞的免疫等。该文综述LAG-3在免疫细胞调节中的功能和机制，及其参与抗肿瘤治疗及药物研发的进展，为LAG-3作为靶点的临床应用和药物研发提供启示。更多还原

【Abstract】 After programmed death receptor-1(PD-1) and cytotoxic T lymphocyte associated protein 4(CTLA-4),the lymphocyte activation gene-3(LAG-3) is becoming a more and more popular immune checkpoint. LAG-3regulates immune system through different signaling pathways. For example, LAG-3 regulates the exhaust,activation, and tumor recognition and killing ability of T cells, as well as the cellular immunity of Treg cells. Here,the function and mechanism of LAG-3 in regulating immune cells, its progress on antitumor immunotherapy and drug development were reviewed, which may provide reference for the LAG-3 based clinical application and drug development.更多还原