【摘要】 香叶基香叶基焦磷酸合酶(geranylgeranyl diphosphate synthase,GGPPS)是甲羟戊酸途径中的一种分支酶，参与蛋白质异戊二烯化。GGPPS通过介导多条细胞信号通路，在细胞的生物学功能和疾病的发生机制中发挥关键作用，调节各种疾病的病理进展。GGPPS在肿瘤中表达异常，而表达水平与预后密切相关，故有望成为肿瘤早期诊治的一种新兴的生物指标。本文主要对GGPPS的生物学功能、在肿瘤中的作用及其抑制剂在肿瘤中的应用进行总结，寻求其在未来肿瘤疾病防治中的潜在价值。更多还原

【Abstract】 Geranylgeranyl pyrophosphate synthase(GGPPS) is a branching enzyme of the mevalonate pathway, involved in protein isoprenylation. By mediating multiple cell signaling pathways, GGPPS plays a key role in the biological function of cells and the pathogenesis of diseases, and regulates the pathological progression of various diseases. There is increasing evidence that GGPPS is abnormally expressed in tumors and that expression levels are closely related to prognosis, thus promising to become an emerging bio-indicator for the early diagnosis and treatment of tumors. This review focuses on the biological functions of GGPPS, its role in tumors and the application of its inhibitors in tumors, seeking its future potential value in the prevention and treatment of oncological diseases.更多还原