【摘要】 目的 研究化瘀清金汤治疗中风相关性肺炎的治疗效果。方法 选取2017年6月—2022年6月期间安徽医科大学附属宿州医院收治的中风相关性肺炎(Stroke-associated pneumonia, SAP)患者110例作为研究对象，采用随机数字表法分为对照组和治疗组，每组各55例。两组患者均给予基础治疗，对照组给予抗生素治疗，治疗组在对照组的基础上加用化瘀清金汤治疗，共用药1周。评估两组患者中医证候积分，比较两组患者症状缓解时间及住院时间，检测两组炎症相关因子[白细胞介素-6(Interleukin-6,IL-6)、C-反应蛋白(C-reactive protein, CRP)、降钙素原(Procalcitonin, PCT)、白细胞计数(White blood cell, WBC)]水平，评定两组患者治疗总有效率，记录两组患者不良反应发生率。结果 治疗后治疗组总有效率92.73%(51/55)优于对照组76.36%(42/55),差异有统计学意义(P<0.05)。治疗后治疗组肺部啰音消失时间、咳嗽缓解时间、退热时间及住院时间均低于对照组，差异有统计学意义(P<0.05)。治疗后两组患者中医证候(咳嗽、咳痰、喘息、发热)积分均低于治疗前，差异有统计学意义(P<0.05);且治疗组低于对照组，差异有统计学意义(P<0.05)。治疗后两组患者血清CRP、PCT、WBC及IL-6水平均低于治疗前，差异有统计学意义(P<0.05);且治疗组均低于对照组，差异有统计学意义(P<0.05)。治疗过程中，治疗组不良反应发生率1.82%与对照组3.64%比较，差异无统计学意义(P>0.05)。结论 SAP患者经化瘀清金汤治疗后，其临床症状明显改善，住院时间明显缩短，血清炎性因子水平明显降低，且用药安全性高。更多还原

【Abstract】 Objective To study the therapeutic effect of Huayu Qingjin Decoction on stroke-associated pneumonia.Methods A total of 110 patients with stroke-related pneumonia admitted to Suzhou Hospital Affiliated to Anhui Medical University from June 2017 to June 2022 were selected as the research subjects, and divided into treatment group(55 cases)and control group(55 cases)by random number table method.Both groups were given basic treatment, the control group was treated with antibiotics, on this basis, the treatment group was treated with Huayu Qingjin Decoction.Both groups were treated for 1 week.The TCM syndrome scores of the two groups were evaluated, the symptom relief time and hospital stay time of the two groups were compared, inflammatory cytokines[Interleukin-6(IL-6),C-reactive protein(CRP),Procalcitonin(PCT),White blood cell(WBC)]level of two groups was detected, the total effective rate of the two groups was assessed, and the incidence of adverse reactions between the two groups was recorded.Results Comparison of total effective rate between the two groups, the treatment group(92.73%)was higher than the control group(76.36%)(P<0.05).Comparison of the disappearance time of pulmonary rales, cough relief time, fever reduction time and hospital stay between the two groups, the treatment group was lower than the control group(P<0.05).After treatment, scores of TCM syndrome(cough, phlegm, wheezing, fever)in two groups were lower than before treatment(P<0.05);and the treatment group was lower than the control group(P<0.05).After treatment, serum CRP,PCT,WBC and IL-6 levels in two groups were lower than before treatmen(P<0.05),and the treatment group was lower than the control group(P<0.05).During the treatment, the incidence of adverse reactions in the treatment group was 1.82% compared with 3.64% in the control group, with no statistical significance(P>0.05).Conclusion Huayu Qingjin Decoction can significantly improve the clinical symptoms, shorten the length of stay, and reduce the level of serum inflammatory factors.It is an effective treatment for SAP patients with high safety.更多还原