【摘要】 癌因性疲乏（CRF）的八纲辨证以阳气虚为本，脏腑辨证以脾肾为要，主要病机为脾气不足、肾精亏虚。基于神经内分泌系统下丘脑-垂体-肾上腺轴（HPA）的特征，以益气温阳理论为契合点，探讨雷火灸在干预免疫检查点抑制剂（ICIs）相关CRF中的作用机制，以期构建CRF治疗的中医学理论指导基础，开拓CRF中医外治思路。更多还原

【Abstract】 Cancer-related fatigue(CRF) is distinguished as deficiency of yang qi in terms of the eight-principle syndrome differentiation, and as deficiency of the spleen and kidneys in terms of the zang-fu syndrome differentiation. The main pathological mechanisms are insufficient spleen qi and deficient kidney essence. Based on the characteristics of the hypothalamic-pituitary-adrenal(HPA) in the neuroendocrine system, with the theory of invigorating qi and warming yang as an entry point, this paper explores the mechanism of action of thunder-fire moxibustion in the intervention of CRF associated with immune checkpoint inhibitors(ICIs). The aim is to establish a theoretical foundation of traditional Chinese medicine(TCM) for the treatment of CRF and to explore the TCM external treatment for CRF.更多还原